Rhavdomyolysis due to an uncommon interaction of ciprofloxacin with simvastatin

SawantR.D.

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Rhavdomyolysis due to an uncommon interaction of ciprofloxacin with simvastatin

机译：环丙沙星与辛伐他汀罕见相互作用引起的横纹肌溶解

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A case report of a ciprofloxacin and simvastatin interaction is presented. The addition of ciprofloxacin to chronic simvastatin therapy led to the development of rhabdomyolysis. As ciprofloxacin is a weak inhibitor of CYP3A4, it is very likely that other mechanisms involving the ATP-binding cassette drug efflux transporter family played a role in this drug interaction.

机译：环丙沙星和辛伐他汀相互作用的病例报告。在慢性辛伐他汀治疗中加入环丙沙星会导致横纹肌溶解的发展。由于环丙沙星是CYP3A4的弱抑制剂，很可能涉及ATP结合盒式药物外排转运蛋白家族的其他机制在这种药物相互作用中也起作用。

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《The Canadian journal of clinical pharmacology =: Journal canadien de pharmacologie clinique》 |2009年第1期|共2页
作者
SawantR.D.;
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正文语种 eng
中图分类药学;
关键词
Ciprofloxacin; Elderly; Polypharmacy; Rhabdomyolysis; Simvastatin;

机译：环丙沙星;老年人;多药;横纹肌溶解;辛伐他汀;

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1. Rhavdomyolysis due to an uncommon interaction of ciprofloxacin with simvastatin [J] . SawantR.D. The Canadian journal of clinical pharmacology =: Journal canadien de pharmacologie clinique . 2009,第1期

机译：环丙沙星与辛伐他汀罕见相互作用引起的横纹肌溶解
2. Simvastatin-tacrolimus and simvastatin-cyclosporin interactions in rats. [J] . Yamada H, Kotaki H, Sawada Y, Biopharmaceutics and Drug Disposition . 1998,第5期

机译：大鼠辛伐他汀-他克莫司和辛伐他汀-环孢菌素的相互作用。
3. Validated UPLC-MS/MS method for simultaneous determination of simvastatin, simvastatin hydroxy acid and berberine in rat plasma: Application to the drug-drug pharmacokinetic interaction study of simvastatin combined with berberine after oral administration in rats [J] . Liu Mei, Su Xianying, Li Guofei, Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2015,第Null期

机译：经验证的UPLC-MS / MS方法同时测定大鼠血浆中的辛伐他汀，辛伐他汀羟酸和小ber碱：辛伐他汀联合小ber碱在大鼠口服给药后在药物药代动力学研究中的应用
4. Hybrid material (chitosan hydrogel/bioceramic) loaded with ciprofloxacin or simvastatin for bone reconstruction [C] . Claudia Flores, Jean Christophe Hornez, Feng Chai, 26th European conference on biomaterials 2014 . 2014

机译：载有环丙沙星或辛伐他汀的混合材料（壳聚糖水凝胶/生物陶瓷）用于骨重建
5. A New Mechanism of Serotonin Transporter Regulation by Simvastatin and the Isoprenylation Pathway [D] . Deveau, Carmen Marie. 2021

机译：辛伐他汀与异戊二烯途径的血清素转运蛋白调控的新机制
6. Ciprofloxacin: an uncommon drug reaction to a commonly used drug [O] . Pedro Mendes-Bastos, Rodrigo Carvalho, Daniela Cunha, 2014

机译：环丙沙星：对常用药物的罕见药物反应
7. Ciprofloxacin: an Uncommon Drug Reaction to a Commonly Used Drug [O] . Mendes-Bastos P, Carvalho R, Cunha D, 2014

机译：环丙沙星：对常用药物的罕见药物反应

Rhavdomyolysis due to an uncommon interaction of ciprofloxacin with simvastatin

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