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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Long-Term Stability of 5-Fluorouracil in 0.9% Sodium Chloride after Freezing, Microwave Thawing, and Refrigeration
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Long-Term Stability of 5-Fluorouracil in 0.9% Sodium Chloride after Freezing, Microwave Thawing, and Refrigeration

机译：冷冻，微波解冻和冷藏后5-氟尿嘧啶在0.9％氯化钠中的长期稳定性

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摘要

Objective: To investigate the stability of 5-fluorouracil diluted in 0.9% sodium chloride (normal saline [NS]) after freezing, microwave thawing, and storage for 28 days at 5deg C +- 3deg C.Methods: Polyvinylchloride (PVC) infusion bags (n = 5) containing 5-fluorouracil 800 mg/100 mL were frozen for 79 days at -20deg C. The bags were then thawed in a microwave oven and stored at 5deg C +- 3deg C for 28 days. The concentration of 5-fluorouracil was measured by high-performance liquid chromatography. Visual and microscopic inspections were performed and pH was measured periodically during storage. Solutions were considered stable if the lower limit of the 95% confidence interval of the concentration versus time profile remained greater than 90% of the initial concentration.Results: No colour change or precipitation was observed in any of the solutions. Slight changes in pH were observed during refrigeration. 5-Fluorouracil solutions were stable during storage at 5deg C +- 3deg C for 28 days, as indicated by the results of high-performance liquid chromatography.Conclusion: 5-Fluorouracil 8 mg/mL in NS may be prepared in advance, frozen and stored in PVC bags, and thawed before use. The solutions remained stable after freezing at -20deg C for 79 days followed by storage at 5deg C +- 3deg C for up to 28 days.
机译：目的：研究在0.9％氯化钠（生理盐水[NS]）中稀释的5-氟尿嘧啶在冷冻，微波解冻和在5℃±3℃下储存28天后的稳定性。方法：聚氯乙烯（PVC）输液袋将含有800mg / 100mL的5-氟尿嘧啶（n ＝ 5）（n ＝ 5）在-20℃冷冻79天。然后将袋在微波炉中解冻，并在5℃±3℃下保存28天。通过高效液相色谱法测定5-氟尿嘧啶的浓度。在储存过程中进行视觉和显微镜检查并定期测量pH。如果浓度与时间曲线的95％置信区间的下限保持大于初始浓度的90％，则认为溶液是稳定的。结果：在任何溶液中均未观察到颜色变化或沉淀。在冷藏过程中观察到pH值的轻微变化。如高效液相色谱法所示，5-氟尿嘧啶溶液在5°C + -3°C下保存28天稳定。结论：可以预先制备5 mg / mL NS中的5-氟尿嘧啶，将其冷冻并冷冻。存放在PVC袋中，使用前要解冻。在-20℃冷冻79天后，在5℃±3℃下保存最多28天后，溶液保持稳定。

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