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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Effect of Utilization Policies for Fluoroquinolones: A Pilot Study in Nova Scotia Hospitals
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Effect of Utilization Policies for Fluoroquinolones: A Pilot Study in Nova Scotia Hospitals

机译：氟喹诺酮类药物利用政策的影响：新斯科舍省医院的一项初步研究

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Background: Antimicrobial resistance results in increased morbidity, mortality, and costs to the health care system. Evidence suggests an association between the use of antimicrobials in hospitals and the development of antimicrobial resistance. Fluoroquinolones constitute one group of antimicrobials that are effective against a variety of bacterial infections, yet they may be subject to misuse. Many hospitals in Nova Scotia have implemented policies to improve antimicrobial prescribing, but the impact of these policies on utilization is unknown.Objectives: To evaluate the use of fluoroquinolones in Nova Scotia hospitals using the World Health Organizations Anatomical Therapeutic Chemical classification system with defined daily doses (ATC/DDD) and to examine the influence of hospital policies for utilization of fluoroquinolones in community-acquired pneumonia.Methods: During the study period (April 1, 1997, to March 31, 2003), fluoroquinolones were administered at 31 of the 37 hospitals in Nova Scotia's 9 district health authorities. Hospital administrative data, hospital characteristics, and pharmaceutical purchasing data related to use of these drugs were aggregated using the ATC/DDD methodology for the fiscal years 1997/1998 to 2002/2003. District pharmacy directors were surveyed to obtain information about district and individual hospital antibiotic policies. Descriptive statistics were calculated, and univariable regression and multilevel analyses were performed.Results: Mean overall fluoroquinolone use increased over the study period, from 47.2 DDD/1000 bed-days per year in fiscal year 1997/1998 to 163.8 DDD/1000 bed-days per year in fiscal year 2002/2003 (p < 0.001). Multilevel analysis showed that utilization policies aimed at appropriate prescribing did not affect the use of fluoroquinolones.Conclusion: This study revealed that drug purchasing, hospital administrative, and diagnostic data could be combined to compare the utilization of fluoroquinolones among different hospitals and district health authorities. Utilization policies had little effect on the amount, type, or route of fluoroquinolone use.
机译：背景：抗菌素耐药性会增加发病率，死亡率，并增加医疗保健系统的成本。有证据表明，医院使用抗菌药物与抗菌素耐药性的发展之间存在关联。氟喹诺酮类药物可有效抵抗多种细菌感染，但可能会被滥用。新斯科舍省的许多医院已经实施了改善抗菌素处方的政策，但这些政策对利用率的影响尚不明确。目的：使用世界卫生组织解剖治疗化学分类系统（每日定义剂量）评估新斯科舍省医院氟喹诺酮类药物的使用情况（ATC / DDD），并研究医院政策对社区获得性肺炎中氟喹诺酮类药物的利用方法。方法：在研究期间（1997年4月1日至2003年3月31日），在37例中的31例中使用了氟喹诺酮类药物新斯科舍省9个地区卫生部门的医院。使用ATC / DDD方法汇总了1997/1998到2002/2003财政年度与这些药物使用相关的医院行政数据，医院特征和药品购买数据。对地区药房主任进行了调查，以获取有关地区和个别医院抗生素政策的信息。结果：研究期间平均氟喹诺酮使用量从1997/1998财政年度的每年47.2 DDD / 1000床日增加到163.8 DDD / 1000床日。每年2002/2003财政年度（p <0.001）。多层次分析表明，针对适当处方的使用政策不会影响氟喹诺酮类药物的使用。结论：这项研究表明，可以将药品购买，医院行政管理和诊断数据结合起来，比较不同医院和地区卫生部门之间氟喹诺酮类药物的使用情况。使用政策对氟喹诺酮的使用量，类型或途径影响不大。

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