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NeuroAIDS in West Africa: a full circle. sciences neurologiques

机译:西非的NeuroAIDS:一个完整​​的圈子。科学神经学

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摘要

Over 38 million people are currently infected by the human immunodeficiency virus type 1 (HIV-1) (www.unaids.org). Human immunodeficiency virus type 1. is a retrolentivirus causing immunosuppression, which progresses to the acquired immunodeficiency syndrome (AIDS) and eventual death. HIV-l's origins in human lie in its evolution from the simian immunodeficiency virus infection in nonhuman primates and subsequent transmission to humans in central Africa, likely through the bushmeat industry. HTV infection has ravaged sub-Saharan Africa exerting profound health, social, economic and political effects that will last for generations. HIV-1 is neurotropic (infects the nervous system) and is neurovirulent (causes disease in the nervous system).1 The nervous system is infected immediately after primary HIV infection with rapidly ensuing subclinical neurological injury. In fact, the severity and frequency of HIV-induced neurological disorders are influenced by host neurosusceptibility, which are determined byfactors including host age, genetic polymorphisms, level of immunosuppression and concurrent infections, together with the ability of the host to contain infection at the time of primary infection.
机译:目前,有超过3800万人感染了1型人类免疫缺陷病毒(www.unaids.org)。 1型人类免疫缺陷病毒是引起免疫抑制的逆转录病毒,可发展为获得性免疫缺陷综合症(AIDS)并最终死亡。 HIV-1的起源于人类,它是由猿猴免疫缺陷病毒在非人类灵长类动物中的感染演变而来,并随后可能通过食用森林猎物业传播给中部非洲人。 HTV感染使撒哈拉以南非洲遭受重创,其健康,社会,经济和政治影响将持续数代之久。 HIV-1具有嗜神经性(感染神经系统)和神经毒力(导致神经系统疾病)。1原发性HIV感染后,神经系统即刻受到感染,并迅速导致亚临床神经损伤。实际上,HIV诱发的神经系统疾病的严重程度和频率受宿主神经敏感性的影响,宿主神经敏感性的确定因素包括宿主年龄,遗传多态性,免疫抑制水平和并发感染,以及宿主当时控制感染的能力原发感染。

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