• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Effect of therapy on motor cortical excitability in Parkinson's disease.
【24h】

Effect of therapy on motor cortical excitability in Parkinson's disease.

机译：治疗对帕金森氏病运动皮层兴奋性的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To assess the impact of the disease stage and therapy on motor cortical excitability in Parkinson's disease (PD). METHODS: Twenty newly diagnosed and medication-free, early stage patients, 20 late stage patients under antiparkinsonian therapy and 20 normal healthy controls were included. Motor threshold (MT), amplitudes of motor evoked potential (MEP), motor evoked potential amplitude/compound muscle action potential amplitude (MEP/CMAP) ratio, central motor conduction time (CMCT) and cortical silent period (CSP) were measured by stimulation of the motor cortex using a 13.5 cm circular coil and recordings from abductor digiti minimi muscle. Following the first study protocol, early stage patients were given therapy and the same protocol was repeated three months later. RESULTS: Motor threshold was lower; and the MEP/CMAP ratio was higher in early and late stage patients than normals. In early stage patients after proper therapy, the MTs became higher than before therapy, but still remained lower than normals. In late stage patients, the CMCTs were shorter than the early stage patients before therapy and normals, but there was no difference between the early stage patients and normals. In early stage patients after therapy, the CMCT became longer than before therapy and this difference was significant in both late stage patients and normals. Although more prominent in late stage patients, the CSP duration in both PD groups was found shorter than normals. In early stage patients, after therapy, the CSP durations became significantly longer compared with before therapy. CONCLUSION: These findings suggest that the motor cortical excitability increases in PD because of the impairment of the corticomotoneuronal inhibitory system.
机译：目的：评估帕金森病（PD）的疾病阶段和治疗方法对运动皮层兴奋性的影响。方法：包括20名新诊断和免药的早期患者，20例接受抗帕金森病治疗的晚期患者和20名正常健康对照者。通过刺激测量运动阈值（MT），运动诱发电位（MEP）的幅度，运动诱发电位幅度/复合肌肉动作电位幅度（MEP / CMAP）之比，中枢运动传导时间（CMCT）和皮质沉默期（CSP）使用13.5厘米的圆形线圈记录运动皮层，并记录数位外展肌的记录。根据第一个研究方案，对早期患者进行治疗，并在三个月后重复相同的方案。结果：运动阈值较低。早期和晚期患者的MEP / CMAP比值均高于正常人。在经过适当治疗的早期患者中，MT高于治疗前，但仍低于正常水平。在晚期患者中，CMCT比在治疗前的早期患者和正常人短，但是早期患者和正常人之间没有差异。在治疗后的早期患者中，CMCT比治疗前更长，这种差异在晚期患者和正常人中均显着。尽管在晚期患者中更为突出，但发现两个PD组的CSP持续时间都比正常人短。在早期患者中，治疗后的CSP时间比治疗前明显更长。结论：这些发现提示PD的运动皮层兴奋性增加是由于皮质单神经递质抑制系统的损伤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号