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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Endothelial progenitor cells in patients with acute cerebrovascular ischemia.
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Endothelial progenitor cells in patients with acute cerebrovascular ischemia.

机译:急性脑血管缺血患者的内皮祖细胞。

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OBJECTIVE: Statins have been shown to increase endothelial progenitor cells (EPCs) in patients with cardiovascular disease. However, there is no similar study that has been done on the patients recovering from cerebrovascular disease. We present the largest prospective study of statin therapy on EPC levels of patients recovering from stroke. METHOD: Our study subjects were treated with rosuvastatin (10 mg/day) over a period of 12 weeks. Blood was collected from these patients periodically and EPC levels were measured along with other biochemical parameters. RESULTS AND CONCLUSIONS: Our study shows that rosuvastatin treatment significantly reduces the low density lipoprotein (LDL) levels in the patients over the 12 weeks. However, we did not find any corresponding changes in the EPC levels during this time period. Earlier reports indicated that statin use could increase EPC proliferation. Our research, however, indicates that the in-vivo effects of rosuvastatin are not similar to those of previous reports. There may be several reasons for this lack of congruence between these two studies, including age of the study population, predominantly low high density lipoprotein (HDL) levels in our subjects and effects from other concomitant medications.
机译:目的:他汀类药物已显示可增加心血管疾病患者的内皮祖细胞(EPC)。但是,对于从脑血管疾病中康复的患者,没有类似的研究。我们提出了他汀类药物治疗中风康复患者EPC水平的最大前瞻性研究。方法:我们的研究对象在12周内接受瑞舒伐他汀(10毫克/天)治疗。定期从这些患者中收集血液,并测量EPC水平以及其他生化参数。结果与结论:我们的研究表明,瑞舒伐他汀治疗可在12周内显着降低患者的低密度脂蛋白(LDL)水平。但是,在此期间,我们没有发现EPC级别有任何相应的变化。较早的报道表明,他汀类药物的使用可能会增加EPC的增殖。然而,我们的研究表明,瑞舒伐他汀在体内的作用与以前的报道不同。两项研究之间缺乏一致性的原因可能很多,包括研究人群的年龄,受试者中高密度脂蛋白(HDL)水平低以及其他伴随药物的影响。

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