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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Subcortical hyperexcitability in migraineurs: a high-frequency oscillation study.
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Subcortical hyperexcitability in migraineurs: a high-frequency oscillation study.

机译：偏头痛的皮层下超兴奋性：高频振荡研究。

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摘要

OBJECTIVE: An abnormal central nervous system excitability level was found in patients with migraine. Whether it is hyper- or hypo-excitable is still debated. This study aimed to compare the somatosensory high-frequency oscillations (HFOs), which reflected subcortical excitability (early phase) and intracortical inhibition (late phase), between patients with migraine and control subjects. METHODS: HFOs were recorded from C3'-Fz, using a 500-1000 Hz frequency filter after stimulation at right median nerves at the wrists, and divided into early and late phases based on the N20 peak. Fifty-nine untreated patients (n=24 during ictal period; n=35, interictal) and 22 controls finished the study. RESULTS: In early HFOs, patients both during ictal and interictal periods had higher maximal amplitudes (p=0.039) and area-under-curve (p=0.029) than those of the controls. Regarding the late HFOs, there were no significant differences among these groups. CONCLUSION: Our study suggests a hyper-excitable state in the subcortical regions in patients with migraine both during interictal and ictal periods.
机译：目的：发现偏头痛患者的中枢神经系统兴奋性水平异常。无论是过度兴奋还是次兴奋。这项研究旨在比较偏头痛患者与对照组之间的体感高频振荡（HFO），它们反映了皮层下兴奋性（早期）和皮层内抑制（晚期）。方法：在手腕右侧正中神经刺激后，使用500-1000 Hz频率滤波器从C3'-Fz记录HFO，并根据N20峰分为早期和晚期。 59名未经治疗的患者（在发作期n = 24;发作间期n = 35）和22名对照组完成了研究。结果：在早期的HFO中，在发作期和发作间期患者的最大幅度（p = 0.039）和曲线下面积（p = 0.029）均高于对照组。关于晚期HFO，这些组之间没有显着差异。结论：我们的研究表明偏头痛患者在发作期和发作期均处于皮质下区域的过度兴奋状态。

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