• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Meta-analysis of aldehyde dehydrogenase 2 gene polymorphism and Alzheimer's disease in East Asians.
【24h】

Meta-analysis of aldehyde dehydrogenase 2 gene polymorphism and Alzheimer's disease in East Asians.

机译：乙醛脱氢酶2基因多态性与阿尔茨海默氏病的Meta分析。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: The association of genetic polymorphism of mitochondrial aldehyde dehydrogenase 2 (ALDH2) and Alzheimer's disease (AD) has been controversial and has been investigated only in several small-sample studies. In the present study, we performed a meta-analysis to evaluate the cross-sectional association of ALDH2 variants and AD risk in East Asian populations. METHODS: Trials were retrieved through MEDLINE, EMBASE, J-STAGE and the China National Knowledge Internet databases (from January 1, 1994 to November 1, 2010) without any restriction on language. Data were abstracted by a standardized protocol. RESULTS: We found four studies of 821AD patients and 1380 healthy controls that qualified for the analysis. The variant ALDH2 genotype GA/AA was not associated with increased AD risk (odds ratio (OR) = 1.35; 95% confidence interval (CI) = 0.75-2.42; p = 0.32), even after stratification for the status of apolipoprotein E epsilon 4 allele. However, in the subgroup analyses, the association was significant for men (OR = 1.72; 95% CI = 1.10-2.67; p = 0.02). CONCLUSIONS: This study adds to the evidence that ALDH2 GA/AA genotype increases the risk of AD among East Asian men, although the effect size is moderate.
机译：背景：线粒体醛脱氢酶2（ALDH2）的遗传多态性与阿尔茨海默氏病（AD）的关联一直存在争议，仅在几个小样本研究中进行了研究。在本研究中，我们进行了荟萃分析，以评估ALDH2变体的横断面关联与东亚人群的AD风险。方法：从MEDLINE，EMBASE，J-STAGE和中国国家知识互联网数据库（从1994年1月1日至2010年11月1日）检索试验，而不受语言限制。通过标准化协议对数据进行抽象。结果：我们发现有821例AD患者和1380例健康对照符合条件的四项研究。即使将载脂蛋白Eε的状态分层后，变体ALDH2基因型GA / AA也不与AD风险增加相关（奇数比（OR）= 1.35; 95％置信区间（CI）= 0.75-2.42; p = 0.32）。 4个等位基因。但是，在亚组分析中，该关联对于男性是显着的（OR = 1.72; 95％CI = 1.10-2.67; p = 0.02）。结论：本研究增加了证据，尽管影响规模中等，但ALDH2 GA / AA基因型增加了东亚男性AD的风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号