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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Stroke genetics and the Chinese population.
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Stroke genetics and the Chinese population.

机译：中风遗传学与中国人口。

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摘要

Stroke is the third most common cause of death and the most common cause of disability in developed countries.1 About 80% of strokes are ischemic. Atherosclerosis, cardioembolism, and small-vessel disease are the most common causes. Non-modifiable risk factors (age, African and Asian race, male sex) and acquired risk factors (hypertension, cigarette smoking, diabetes, atrial fibrillation, and obesity) account for a large part of the risk of ischemic stroke. Yet, stroke risk remains insufficiently explained by these factors. Studies in twins, families, and animal models provide substantial evidence for a genetic contribution to ischemic stroke. Genetic factors seem to be more important in large-vessel stroke and small-vessel stroke than in cryptogenic stroke. Genetic factors can contribute to conventional risk factors such as hypertension, diabetes, or homocysteine concentrations.
机译：在发达国家，中风是第三大最常见的死亡原因，也是最常见的致残原因。1大约80％的中风是缺血性的。动脉粥样硬化，心脏栓塞和小血管疾病是最常见的原因。不可改变的危险因素（年龄，非洲和亚洲种族，男性）和后天的危险因素（高血压，吸烟，糖尿病，心房纤颤和肥胖）占缺血性中风的很大一部分。然而，这些因素仍不足以解释中风风险。对双胞胎，家庭和动物模型的研究为遗传性缺血性卒中的发生提供了重要的证据。遗传因素似乎在大血管卒中和小血管卒中中比在隐源性卒中中更为重要。遗传因素可导致常规风险因素，例如高血压，糖尿病或高半胱氨酸浓度。

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