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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >T2 and DWI in pilocytic and pilomyxoid astrocytoma with pathologic correlation
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T2 and DWI in pilocytic and pilomyxoid astrocytoma with pathologic correlation

机译：T2和DWI在毛细血管和绒毛状星形细胞瘤中的病理相关性

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摘要

Objective: To quantify and compare T2 signal and apparent diffusion coefficient (ADC) in pilocytic and pilomyxoid astrocytoma (PA and PMA) and correlate results with myxoid content. Methods: Echo-planar diffusion weighted images (DWI) and standard magnetic resonance imaging (MRI) findings were reviewed retrospectively in patients with PA (n=34) and PMA (n=8). Regions of interest (ROIs) were drawn on ADC maps within tumor parts with lowest ADC values. Apparent diffusion coefficient values in tumor were normalized to those in cerebrospinal fluid (ADC/CSF). The ratio of T2 signal intensity in solid tumor parts to CSF (T2/CSF) was registered. Myxoid matrix was histologically quantified retrospectively in 8 PMAs and 17 PAs and correlated with imaging findings. Results: Mean ADC/CSF for PA and PMA was 0.53±0.10 and 0.69±0.10 (p<0.01). Mean T2/CSF for PA and PMA was 0.78±0.19 and 0.93±0.09 (p<0.01). Mean proportion of myxoid tumor matrix in PA was 50% (range, 10-100%) and 93% (range, 90-100%) in PMA (p=0.004). Eight patients (32%; all PA) had less than 50% myxoid content and 17 (68%; 8 PA; 9 PMA) had more. There was positive correlation of ADC/CSF, T2/CSF and ADC (r2=0.61, 0.65 and 0.60 respectively) and significant difference between the groups with more and less than 50% myxoid content (p=0.01 for ADC/CSF and T2/CSF and p=0.02 for ADC). Conclusions: General imaging features of PA and PMA are non-specific, ADC values and T2 signal intensity are generally higher in the latter, reflecting the proportion of myxoid matrix in these tumors.
机译：目的：定量和比较毛细血管和绒毛状星形细胞瘤（PA和PMA）中的T2信号和表观扩散系数（ADC），并将结果与​​类固醇含量相关联。方法：回顾性分析PA（n = 34）和PMA（n = 8）患者的超声平面扩散加权图像（DWI）和标准磁共振成像（MRI）结果。在具有最低ADC值的肿瘤部位内的ADC图上绘制感兴趣区域（ROI）。将肿瘤中的表观扩散系数值标准化为脑脊液（ADC / CSF）中的值。记录实体瘤部分中T2信号强度与CSF的比率（T2 / CSF）。对8个PMA和17个PA中的粘液样基质进行组织学回顾性分析，并与影像学发现相关。结果：PA和PMA的平均ADC / CSF为0.53±0.10和0.69±0.10（p <0.01）。 PA和PMA的平均T2 / CSF为0.78±0.19和0.93±0.09（p <0.01）。 PA中粘液样肿瘤基质的平均比例在PMA中分别为50％（范围10-100％）和93％（范围90-100％）（p = 0.004）。 8名患者（32％;全部PA）的类固醇含量低于50％，17名患者（68％; 8 PA; 9 PMA）更多。 ADC / CSF，T2 / CSF和ADC呈正相关（分别为r2 = 0.61、0.65和0.60），糊状蛋白含量大于或小于50％的组之间存在显着差异（ADC / CSF和T2 / p = 0.01 CSF，对于ADC，p = 0.02）。结论：PA和PMA的一般影像学特征是非特异性的，后者的ADC值和T2信号强度通常更高，反映了这些肿瘤中粘液样基质的比例。

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