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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >CD226 Gly307Ser association with neuromyelitis optica in southern Han Chinese
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CD226 Gly307Ser association with neuromyelitis optica in southern Han Chinese

机译：CD226 Gly307Ser与南方汉族人视神经脊髓炎的相关性

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摘要

Background: Neuromyelitis optica (NMO) and multiple sclerosis (MS) are autoimmune diseases of the central nervous system with complex pathogeneses. NMO was once considered to be a severe variant of MS. There has been more evidence that a non-synonymous exchange (rs763361/Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including multiple sclerosis (MS). However, no studies have investigated the role of rs763361 in the pathogenesis of NMO. Objectives: The goal of our study is to evaluate the role of CD226 Gly307Ser in neuromyelitis optica (NMO) in Southern Han Chinese. Methods: Eight-nine NMO patients, 93 relapsing-remitting multiple sclerosis (RRMS) patients, and 122 controls (CTLs) were enrolled. The rs763361 alleles of the subjects were determined by sequencing-based typing. Results: The results strongly support that the TT genotypes are associated with NMO but are not significantly correlated with susceptibility for MS. Conclusions: CD226 Gly307Ser may correlate with risk of NMO in Southern Han Chinese.
机译：背景：视神经脊髓炎（NMO）和多发性硬化症（MS）是具有复杂病原体的中枢神经系统自身免疫性疾病。 NMO曾经被认为是MS的严重变异。已有更多证据表明CD226基因中的非同义交换（rs763361 / Gly307Ser）与多种自身免疫性疾病（包括多发性硬化症（MS））有关。但是，尚无研究调查rs763361在NMO发病机理中的作用。目的：本研究的目的是评估CD226 Gly307Ser在中国南方汉族人群视神经脊髓炎（NMO）中的作用。方法：招募了89例NMO患者，93例复发缓解型多发性硬化症（RRMS）患者和122例对照（CTL）。通过基于测序的分型确定受试者的rs763361等位基因。结果：结果强烈支持TT基因型与NMO相关，但与MS易感性无显着相关性。结论：CD226 Gly307Ser可能与南方汉族人的NMO风险有关。

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