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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >The epidemiology of infantile spasms.
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The epidemiology of infantile spasms.

机译：婴儿痉挛的流行病学。

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摘要

OBJECTIVE: The aim of this study was to estimate population based incidence rates for infantile spasms (IS) and to study our clinical impression that the incidence of IS has recently decreased in the Canadian Provinces of Nova Scotia and Prince Edward Island. METHODS: Birth cohorts from 1978 to 1998, identified through the hospital health records, EEG records and physician computerized databases, were followed for two years for the development of IS. Disease incidence rates were calculated using denominators derived from Statistics Canada's reported annual live birth rates. RESULTS: The inclusion criteria for IS were fulfilled by 75 patients. The overall incidence of IS was 30.7/100,000 live births (95% Cl 24.3, 38.8). Etiologic classification was symptomatic for 51 cases (68%), cryptogenic for 18 (24%), and idiopathic in six children (8%). Although there were more males (N=44) than females (N=31), the incidence rates were similar. There was a marked variability in annual and five-year incidence rates. CONCLUSIONS: Although the clinical characteristics of our patients were similar to other reported IS populations, the instability in IS incidence rates indicates a need for caution in interpreting smaller IS epidemiologic studies.
机译：目的：本研究的目的是评估婴儿痉挛症（IS）的人群发病率，并研究我们的临床印象，即加拿大新斯科舍省和爱德华王子岛省的IS发病率最近有所下降。方法：从1978年至1998年通过医院健康记录，EEG记录和医师计算机数据库确定的出生队列，随访了两年以发展IS。疾病发生率是使用加拿大统计局报告的年度活产率得出的分母计算的。结果：75例患者符合IS的纳入标准。 IS的总发生率为30.7 / 100,000活产（95％Cl 24.3、38.8）。病因分类为有症状的51例（68％），隐源性的18例（24％）和特发性的6名儿童（8％）。尽管男性（N = 44）多于女性（N = 31），但发病率相似。年发病率和五年发病率存在明显差异。结论：尽管我们患者的临床特征与其他报道的IS人群相似，但IS发生率的不稳定表明在解释较小的IS流行病学研究时需要谨慎。

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