ESR Measurement Using 2-Diphenylphosphinoyl-2-methyl-3,4-dihydro-2H-pyrrole N-Oxide(DPhPMPO)in Human Erythrocyte Ghosts

Kosei Shioji; Hidefumi Iwashita; Taiji Shimomura

首页> 外文期刊>Bulletin of the Chemical Society of Japan >ESR Measurement Using 2-Diphenylphosphinoyl-2-methyl-3,4-dihydro-2H-pyrrole N-Oxide(DPhPMPO)in Human Erythrocyte Ghosts

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ESR Measurement Using 2-Diphenylphosphinoyl-2-methyl-3,4-dihydro-2H-pyrrole N-Oxide(DPhPMPO)in Human Erythrocyte Ghosts

机译：在人红细胞幽灵中使用2-二苯基膦酰基-2-甲基-3,4-二氢-2H-吡咯N-氧化物（DPhPMPO）进行ESR测量

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Competitive spin-trapping behavior of 2-diphenylphosphinoyl-2-methyl-3,4-dihydro-2H-pyrrole iV-oxide(DPhPMPO)and 2,2-dimethyl-3,4-dihydro-2H-pyrrole N-oxide(DMPO)indicated that the affinity of DPhPMPO for hydroxyl radicals was 1.7 times higher than that of DMPO.Human erythrocyte ghosts(HEGs)with encapsulated Fe~(II)catalysts(HEG-Fe)were prepared for ESR measurement.By trapping the hydroxyl radical(OH~·)in the presence of polyethylene glycol(PEG-4000)outside the HEG-Fe,the generation of OH~· inside the catalyst was confirmed.The trapping of hydroxyl radicals generated in HEG was accomplished using DPhPMPO,and the permeability of the erythrocyte membrane to DPhPMPO was 2.4 times greater than that of DMPO.

机译：2-二苯基膦酰基-2-甲基-3,4-二氢-2H-吡咯iV-氧化物（DPhPMPO）和2,2-二甲基-3,4-二氢-2H-吡咯N-氧化物（DMPO）的自旋俘获行为）表明，DPhPMPO对羟基自由基的亲和力是DMPO的1.7倍。制备了包裹有Fe〜（II）催化剂（HEG-Fe）的人体红细胞幽灵（HEG）用于ESR测量。在HEG-Fe外部存在聚乙二醇（PEG-4000）的情况下，OH〜·）被证实，催化剂内部OH〜·的生成。使用DPhPMPO捕获HEG中生成的羟基自由基，并渗透DPhPMPO的红细胞膜是DMPO的2.4倍。

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《Bulletin of the Chemical Society of Japan》 |2007年第4期|共5页
作者
Kosei Shioji; Hidefumi Iwashita; Taiji Shimomura;
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1. ESR Measurement Using 2-Diphenylphosphinoyl-2-methyl-3,4-dihydro-2H-pyrrole N-Oxide(DPhPMPO)in Human Erythrocyte Ghosts [J] . Kosei Shioji, Hidefumi Iwashita, Taiji Shimomura Bulletin of the Chemical Society of Japan . 2007,第4期

机译：在人红细胞幽灵中使用2-二苯基膦酰基-2-甲基-3,4-二氢-2H-吡咯N-氧化物（DPhPMPO）进行ESR测量
2. Applicability of new spin trap agent, 2-diphenylphosphinoyl-2-methyl-3,4-dihydro-2H-pyrrole N-oxide, in biological system. [J] . Karakawa T, Sato K, Muramoto Y, Biochemical and Biophysical Research Communications . 2008,第1期

机译：新型自旋捕集剂2-二苯基膦酰基-2-甲基-3,4-二氢-2H-吡咯N-氧化物在生物系统中的适用性。
3. STUDIES ON CYCLOADDITION REACTIONS OF 2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRROLE N-OXIDE AND N-(BENZYLIDENE)METHYLAMINE N-OXIDE WITH ALPHA,BETA-UNSATURATED LACTONES AND ESTERS [J] . Baskaran S., Nadkarni PJ., Trivedi GK., Tetrahedron . 1997,第20期

机译：2,2-二甲基-3,4-二氢-2H-吡咯N-氧化物和N-（苄基）甲基亚胺N-氧化物与α，不饱和的内酯和酯的环化反应研究
4. Site-Selective Laser Spectrofluorometry of Human Erythrocytes Ghosts [C] . Kruchenok, Yu.V., Nemkovich, . 1996

机译：人类红细胞鬼魂的定点激光光谱法
5. STUDIES ON THE VIRUS-INDUCED FUSION OF HUMAN ERYTHROCYTE GHOSTS [D] . 関口, 清俊 -1

机译：病毒诱导的人类红细胞幽灵融合的研究
6. FUSION OF INTACT HUMAN ERYTHROCYTES AND ERYTHROCYTE GHOSTS [O] . Hava Peretz, Zivia Toister, Yehudith Laster, 1974

机译：完整的人类红细胞和红细胞幽灵的融合
7. FUSION OF INTACT HUMAN ERYTHROCYTES AND ERYTHROCYTE GHOSTS [O] . Peretz, Hava, Toister, Zivia, Laster, Yehudith, 1974

机译：完整的人类红细胞和红细胞幽灵的融合
8. Investigation of the Interactions of Two Potential Sensing Cyanine Dyes: 3,3'-Dipropylthiadicarbocyanine Iodide and 3,3'-Dipropyloxadicarbocyanine Iodide with Erythrocytes. Ghosts and Phospholipid Vesicles [R] . Guillet, E. G. 1978

机译：两种潜在感应的花青染料的相互作用的研究：3,3'-二丙基噻二羰基碘化物和3,3'-二丙基氧杂二羰基碘与红细胞的相互作用。鬼和磷脂囊泡

ESR Measurement Using 2-Diphenylphosphinoyl-2-methyl-3,4-dihydro-2H-pyrrole N-Oxide(DPhPMPO)in Human Erythrocyte Ghosts

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