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Hepatitis C prevention and treatment for substance users in the United States: acknowledging the elephant in the living room

机译:美国针对吸毒者的丙型肝炎预防和治疗:承认客厅里的大象

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摘要

Like many countries, the United States faces a major epidemic of hepatitis C virus (HC V) infection. Nearly 3 million Americans are estimated to be infected with HCV (Alter et al., 1999), and some 35,000 new infections are believed to occur annually (Williams, 1999). The virus causes chronic infection in about 85% of those infected, and among those chronically infected, cirrhosis may eventually develop in from 5 to 20% (Freeman et al.,2001; Liang, Rehermann, Seeff, & Hoofnagle, 2000). HCV infection is thought to result in 8000-10,000 deaths annually. It is already the most common cause of chronic liver disease and the most common reason for liver transplantation in the United States, and morbidity and mortality from HCV infection are rising and are expected to continue rising in the coming decades (Armstrong, Alter, McQuillan, & Margolis, 2000).
机译:与许多国家一样,美国面临着丙型肝炎病毒(HC V)感染的主要流行病。据估计有将近300万人感染了HCV(Alter等,1999),并且据信每年约有35,000例新感染(Williams,1999)。该病毒在大约85%的感染者中引起慢性感染,在那些慢性感染者中,肝硬化最终可能发展为5%至20%(Freeman等,2001; Liang,Rehermann,Seeff和Hoofnagle,2000)。 HCV感染被认为每年导致8000-10,000例死亡。在美国,它已经成为慢性肝病的最常见原因,也是肝移植的最常见原因,HCV感染的发病率和死亡率正在上升,并且在未来几十年中有望继续上升(Armstrong,Alter,McQuillan, &Margolis,2000)。

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