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首页> 外文期刊>The international journal of developmental biology >Wnt signaling in planarians: New answers to old questions
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Wnt signaling in planarians: New answers to old questions

机译:涡虫中的Wnt信号:旧问题的新答案

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摘要

Wnts are secreted glycoproteins involved in a broad range of essential cell functions, including proliferation, migration and cell-fate determination. Recent years have seen substantial research effort invested in elucidating the role of the Wnt signaling pathway in planarians, flatworms with incredible regenerative capacities. In this review, we summarize current knowledge on the role of canonical (β-catenin-dependent) and non-canonical (β-catenin-independent) Wnt signaling in planarians, not only during regeneration, but also during normal homeostasis. We also describe some of the preliminary data that has been obtained regarding the role of these pathways during embryogenesis. Models are proposed to integrate the different results which have been obtained to date and highlight those questions that still remain to be answered.
机译:Wnt是分泌的糖蛋白,参与广泛的基本细胞功能,包括增殖,迁移和细胞命运测定。近年来,已经进行了大量的研究工作,以阐明Wnt信号通路在涡虫,具有令人难以置信的再生能力的扁虫中的作用。在这篇综述中,我们总结了关于涡旋动物中规范的(β-catenin依赖性)和非规范性的(β-catenin依赖性)Wnt信号作用的当前知识,不仅在再生过程中,而且在正常体内平衡过程中。我们还描述了一些有关胚胎发生过程中这些途径的作用的初步数据。提出了模型,以整合迄今获得的不同结果,并突出显示那些仍有待回答的问题。

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