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首页> 外文期刊>The International journal of eating disorders >A rat in the labyrinth of anorexia nervosa: Contributions of the activity-based anorexia rodent model to the understanding of anorexia nervosa
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A rat in the labyrinth of anorexia nervosa: Contributions of the activity-based anorexia rodent model to the understanding of anorexia nervosa

机译：老鼠在神经性厌食症的迷宫中：基于活动的厌食症啮齿动物模型对理解神经性厌食症的贡献

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Activity-based anorexia (ABA) is an analogous animal model of anorexia nervosa where food-restricted rats develop excessive running activity when given free access to a running wheel; their body weight sharply decreases, and finally self-starvation and death ensue unless animals are removed from the experimental conditions. The parallel of this animal model with major signs in the human disorder has been the focus of much attention from researchers and clinicians as a platform for translational research. The paper reviews the historical antecedents of ABA, research characterizing its occurrence, and its main limitations and strengths as a model of AN. As a symptomatic model of AN, the ABA model can provide clinicians with innovative and alternative routes for improving the treatment of AN.
机译：基于活动的厌食症（ABA）是神经性厌食症的类似动物模型，在这种情况下，受食物限制的老鼠在自由进入跑轮时会产生过度的跑动活动。它们的体重急剧下降，除非动物从实验条件下移开，否则最终将导致自我饥饿和死亡。这种动物模型与人类疾病的主要征兆平行，已成为研究人员和临床医生关注的焦点，以此作为转化研究的平台。本文回顾了ABA的历史先例，研究了其发生的特征，以及它作为AN模型的主要局限性和优势。作为AN的症状模型，ABA模型可以为临床医生提供创新的替代途径，以改善AN的治疗。

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