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首页> 外文期刊>Biological psychiatry >Serotonin 1B receptor imaging in alcohol dependence.
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Serotonin 1B receptor imaging in alcohol dependence.

机译：酒精依赖的血清素1B受体成像。

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BACKGROUND: Although animal models suggest that alcohol dependence (AD) is associated with elevations in the number of serotonin 1B receptors (5-HT(1B)R), 5-HT(1B)R levels have not been investigated in people with AD. The selective 5-HT(1B)R antagonist radioligand, [(11)C]P943, permits in vivo assessment of central 5-HT(1B)R binding potential (BP(ND)) with positron emission tomography. Because of its central role in AD, we were particularly interested in ventral striatal 5-HT(1B)R BP(ND) values. METHODS: Twelve medication-free, recently abstinent (at least 4 weeks) patients with AD (mean age 35.2 +/- 10.2 years, 5 women) and 12 healthy control subjects (HC) (mean age 30.6 +/- 9.2 years, 5 women) completed [(11)C]P943 positron emission tomography on a high-resolution research tomograph. Individual magnetic resonance imaging scans were collected to exclude individuals with anatomical abnormalities and for coregistration. Imaging data were analyzed with a multilinear reference tissue model. RESULTS: Ventral striatal 5-HT(1B)R BP(ND) values (2.01 +/- .57% and 1.55 +/- .09%, respectively; 29% between-group difference, p = .006) were increased in AD compared with HC subjects. No influence of demographic or clinical variables or amount of injected radiotracer was observed. CONCLUSIONS: This study provides the first evidence that AD in humans is, like in rodent models, associated with increased levels of ventral striatal 5-HT(1B)Rs.
机译：背景：尽管动物模型表明酒精依赖性（AD）与血清素1B受体（5-HT（1B）R）数量的增加有关，但尚未在AD患者中研究5-HT（1B）R的水平。选择性的5-HT（1B）R拮抗剂放射性配体[（11）C] P943，可通过正电子发射断层扫描在体内评估中心5-HT（1B）R的结合潜力（BP（ND））。由于其在AD中的重要作用，我们对腹侧纹状体5-HT（1B）R BP（ND）值特别感兴趣。方法：十二名无药物治疗，最近戒酒（至少4周）的AD患者（平均年龄35.2 +/- 10.2岁，5名女性）和12名健康对照者（HC）（平均年龄30.6 +/- 9.2岁，5位女性）在高分辨率研究型X线断层扫描仪上完成了[（11）C] P943正电子发射断层扫描。收集个体磁共振成像扫描以排除具有解剖异常的个体并进行矫正。用多线性参考组织模型分析成像数据。结果：腹侧纹状体5-HT（1B）R BP（ND）值（分别为2.01 +/- .57％和1.55 +/- .09％;组间差异为29％，p = .006） AD与HC受试者相比。没有观察到人口统计学或临床变量或放射性示踪剂注射量的影响。结论：这项研究提供了第一个证据，证明人类AD与啮齿动物模型一样，与腹侧纹状体5-HT（1B）Rs水平升高有关。

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