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首页> 外文期刊>The Journal of Allergy and Clinical Immunology >Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status
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Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status

机译：尽管花生过敏症诊断标准或哮喘状态有所变化，但丝聚蛋白基因突变仍与花生过敏相关

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摘要

Recently, our research team found a strong and significant association between loss-of-function (LOF) mutations in filaggrin (FLG), a gene that encodes a skin barrier protein, in European and Canadian individuals with peanut allergy (PA).1 These mutations result in a barrier defect and have been associated with atopic dermatitis, asthma, and allergic rhinitis.2 This finding represents the strongest genetic risk factor found to date for PA, a highly heritable disease,3 with an estimated odds ratio (OR) between 1.9 (Canadian) and 5.3 (English, Dutch, and Irish combined).1 Because there is no uniformly accepted definition of PA short of oral food challenge, it is worthwhile to examine whether the association between the FLG LOF mutations and PA varies with the diagnostic criteria for PA. Furthermore, the frequent coexistence of PA with other atopic conditions may mean that the association between PA and FLG LOF mutations is confounded.
机译：最近，我们的研究团队在欧洲和加拿大患有花生过敏（PA）的个体中发现，丝蛋白（FLG）的功能丧失（LOF）突变与编码皮肤屏障蛋白的基因之间存在密切而显着的关联。1突变导致屏障缺陷，并与特应性皮炎，哮喘和变应性鼻炎相关。2这一发现代表了迄今为止发现的最强的遗传危险因素，PA是一种高度遗传性疾病，3估计的比值比（OR） 1.9（加拿大）和5.3（英语，荷兰语和爱尔兰语的总和）。1由于没有口服食物挑战，对PA的定义尚无统一的接受，因此有必要研究FLG LOF突变与PA之间的关联是否随食物的变化而变化。 PA的诊断标准。此外，PA与其他特应性疾病的频繁共存可能意味着PA与FLG LOF突变之间的关联是混乱的。

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