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首页> 外文期刊>Biological psychiatry >Primate early life stress leads to long-term mild hippocampal decreases in corticosteroid receptor expression.
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Primate early life stress leads to long-term mild hippocampal decreases in corticosteroid receptor expression.

机译：灵长类动物早期的生活压力导致皮质类固醇受体表达的长期轻度海马区减少。

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BACKGROUND: Expression of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) genes are moderately reduced in several brain regions in depression. These reductions could be partly due to early life stress (ELS), which predicts emotional disorders. Controlled primate studies are important to test whether ELS sufficient to induce long-term emotional changes also induces long-term altered MR and/or GR brain expression. METHODS: In the common marmoset, ELS of daily 30-120-min social isolation across month-1 resulted in some long-term changes in homeostasis and emotional behavior. In some of these same subjects, the aim of this study was to use marmoset-specific riboprobes to determine whether ELS produced long-term effects on brain MR and GR gene expression. RESULTS: At adolescence, relative to control subjects, ELS marmosets exhibited mildly reduced messenger RNA signal for both MR (-15%, p = .05) and GR (-13%, p = .02) in hippocampus-primarily CA1-2-but not in prefrontal cortex, other cortical regions, or hypothalamus. CONCLUSIONS: In adolescent marmoset monkey brains, reduced hippocampal expression of MR and GR are consistent chronic-indicators of ELS. It is unlikely that these chronic, mild, specific reductions were acute-mediators of the observed long-term emotional effects of ELS. However, they do suggest involvement of hippocampal MR/GR in the neurodevelopmental effects of ELS.
机译：背景：在抑郁症的几个大脑区域中，盐皮质激素受体（MR）和糖皮质激素受体（GR）基因的表达适度降低。这些减少的部分原因可能是由于生活早期压力（ELS）预测了情绪障碍。对照的灵长类动物研究对于测试足以诱导长期情绪变化的ELS是否也能引起MR和/或GR脑表达的长期改变非常重要。方法：在普通mar猴中，ELS在第1个月每天进行30-120分钟的社会隔离，导致体内稳态和情绪行为的长期变化。在这些相同的受试者中，这项研究的目的是使用mar猴特异的核糖核苷确定ELS是否对脑MR和GR基因表达产生长期影响。结果：在青春期，相对于对照组，ELS mos猴的海马主要是CA1-2的MR（-15％，p = .05）和GR（-13％，p = .02）的信使RNA信号均轻度降低。 -但不在前额叶皮层，其他皮质区域或下丘脑中。结论：在青春期mar猴的大脑中，MR和GR的海马表达降低是ELS的长期指标。这些慢性的，轻度的，特异性的降低不太可能是观察到的ELS长期情感影响的急性调节剂。但是，他们确实暗示海马MR / GR参与了ELS的神经发育作用。

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