Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis

Kiwamoto Takumi; Katoh Toshihiko; Evans Christopher M.; Janssen William J.; Brummet Mary E.; Hudson Sherry A.; Zhu Zhou; Tiemeyer Michael; Bochner Bruce S.

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Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis

机译：内源性气道黏蛋白携带结合Siglec-F并诱导嗜酸性粒细胞凋亡的聚糖

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Background: Sialic acid-binding, immunoglobulin-like lectin (Siglec) F is a glycan-binding protein selectively expressed on mouse eosinophils. Its engagement induces apoptosis, suggesting a pathway for ameliorating eosinophilia in the setting of asthma and other eosinophil-associated diseases. Siglec-F recognizes sialylated sulfated glycans in glycan-binding assays, but the identities of endogenous sialoside ligands and their glycoprotein carriers in vivo are unknown.

机译：背景：唾液酸结合的免疫球蛋白样凝集素（Siglec）F是一种在小鼠嗜酸性粒细胞上选择性表达的聚糖结合蛋白。它的参与诱导细胞凋亡，提示在哮喘和其他嗜酸性粒细胞相关疾病中，改善嗜酸性粒细胞增多的途径。 Siglec-F在聚糖结合测定中识别唾液酸化的硫酸化聚糖，但体内内源性唾液酸配体及其糖蛋白载体的身份尚不清楚。

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《The Journal of Allergy and Clinical Immunology》 |2015年第5期|共21页
作者
Kiwamoto Takumi; Katoh Toshihiko; Evans Christopher M.; Janssen William J.; Brummet Mary E.; Hudson Sherry A.; Zhu Zhou; Tiemeyer Michael; Bochner Bruce S.;
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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Eosinophil; asthma; Siglec-F; mucin; Muc5b; Muc4; apoptosis; glycan ligands; epithelium; glands; lung; airway;

机译：嗜酸性粒细胞;哮喘;Siglec-F;粘蛋白;Muc5b;Muc4;凋亡;聚糖配体;上皮;腺体;肺;气道;

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1. Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis [J] . Kiwamoto Takumi, Katoh Toshihiko, Evans Christopher M., The Journal of Allergy and Clinical Immunology . 2015,第5期

机译：内源性气道黏蛋白携带结合Siglec-F并诱导嗜酸性粒细胞凋亡的聚糖
2. Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6'-sulfo-sialyl Lewis X as a preferred glycan ligand. [J] . Tateno H, Crocker PR, Paulson JC Glycobiology. . 2005,第11期

机译：小鼠Siglec-F和人Siglec-8是功能趋同的旁系同源物，它们在嗜酸性粒细胞上选择性表达，并将6'-磺基唾液酸路易斯X识别为优选的聚糖配体。
3. Recombinant mucin-type proteins carrying LacdiNAc on different O-glycan core chains fail to support H. pylori binding [J] . Yolanda H. Mthembu, Chunsheng Jin, Medea Padra, Molecular BioSystems . 2020,第3期

机译：携带Lacdinac在不同O-聚糖核心链上的重组粘蛋白型蛋白不能支持H. Pylori结合
4. A Tryptophan Pyrolysis Product, 3-Amino-1,4- dimethyl-5H-pyrido4,3-bindole(Trp-P-1) but Not Its Metabolite Induces Apoptosis in Primary Cultured Rat Hepatocytes: Induction of CYP 1A Interfaces Trp-P-1-Induced Apoptosis [C] . Bunsyo Shiotani, Hitoshi Ashida, Yuji Nonaka, Symposium on food factors in health promotion and disease prevention . 2003

机译：色氨酸热解产物，3-氨基-1,4-二甲基-5H-吡啶4,3-B吲哚（TRP-P-1）但不是其代谢物在原发性培养大鼠肝细胞中诱导细胞凋亡：CYP 1A界面的诱导TRP-P-1诱导的细胞凋亡
5. Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis [O] . Takumi Kiwamoto, Toshihiko Katoh, Christopher M. Evans, -1

机译：内源性气道黏蛋白携带结合Siglec-F并诱导嗜酸性粒细胞凋亡的聚糖
6. Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis [O] . Takumi Kiwamoto, Toshihiko Katoh, Christopher M. Evans, 2015

机译：内源性气道粘蛋白携带结合Siglec-F的聚糖并诱导嗜酸性粒细胞凋亡

Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis

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