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首页> 外文期刊>Biological psychiatry >Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma.
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Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma.

机译：甲基化很重要：甲基化密度和5-羟色胺转运蛋白基因型之间的相互作用预示着未解决的损失或创伤。

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摘要

BACKGROUND: Do genetic or epigenetic factors play a role in making some individuals more vulnerable than others to loss of attachment figures or other traumatic experiences? METHODS: DNA was obtained from growth phase entrained Epstein-Barr Virus (EBV) transformed lymphoblast cell lines from 143 adopted participants. Genotype of the serotonin transporter linked polymorphic region (5HTTLPR) was determined, and methylation ratios for each of the C-phosphate-G (CpG) residues were assessed using quantitative mass spectroscopy. Unresolved loss or trauma was established using the Berkeley Adult Attachment Interview. RESULTS: Higher levels of methylation of the 5HTT promoter associated CpG island were associated with increased risk of unresolved responses to loss or other trauma in carriers of the usually protective 5HTTLPR//variant. The ss variant of 5HTTLPR predicted more unresolved loss or trauma, but only in case of lower levels of methylation. Higher levels of methylation of the ss variant were associated with less unresolved loss or other trauma. CONCLUSIONS: Associations between 5HTTLPR polymorphisms and psychological problems are significantly altered by environmentally induced methylation patterns. Methylation may serve as the interface between adverse environment and the developing organism.
机译：背景：遗传因素或表观遗传因素是否使某些人比其他人更容易丧失依恋形象或其他创伤经历？方法：从143名接受研究的参与者的生长期携带的爱泼斯坦-巴尔病毒（EBV）转化的淋巴母细胞细胞系中获得DNA。确定了5-羟色胺转运蛋白连接的多态性区域（5HTTLPR）的基因型，并使用定量质谱法评估了每个C-磷酸-G（CpG）残基的甲基化率。使用伯克利成人依恋访谈确定了无法解决的损失或创伤。结果：5HTT启动子相关的CpG岛甲基化水平较高，通常对具有保护性的5HTTLPR //变体的携带者对丢失或其他创伤的未解决反应风险增加。 5HTTLPR的ss变体预测更多未解决的损失或创伤，但仅在甲基化水平较低的情况下。 ss变异体甲基化水平越高，未解决的丢失或其他创伤越少。结论：5HTTLPR多态性与心理问题之间的关联被环境诱导的甲基化模式大大改变。甲基化可能是不利环境与发育中生物之间的界面。

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