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首页> 外文期刊>Biological psychiatry >Psychological and somatic symptoms of anxiety and risk of coronary heart disease: the health and social support prospective cohort study.
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Psychological and somatic symptoms of anxiety and risk of coronary heart disease: the health and social support prospective cohort study.

机译：焦虑的心理和躯体症状以及冠心病的风险：健康和社会支持的前瞻性队列研究。

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BACKGROUND: Despite evidence showing anxiety to be a negative emotion that can be accompanied by various psychological and somatic complaints, previous studies have rarely considered these two components of anxiety separately in relation to coronary heart disease (CHD) events. This study aims to examine the extent to which the psychological and somatic components of anxiety are predictive of CHD. METHODS: This is a prospective population-based cohort study of 24,128 participants (9830 men, 14,298 women) aged 20 to 54 years. Psychological and somatic symptoms were assessed at study baseline in 1998. Fatal and nonfatal CHD events during the following 7 years were documented from data on hospitalizations from the National Hospital Discharge Register and mortality records from the Statistics Finland Register. RESULTS: In men, unadjusted hazard ratios for CHD per one unit increase in mean score were 1.50 (95% confidence interval [CI], 1.21-1.87) for somatic symptoms and 1.04 (95% CI, .85-1.29) for psychological symptoms. After serial adjustment for sociodemographic characteristics, biobehavioral risk factors, and clinically significant symptoms of depression, these associations were completely attenuated. In women, the corresponding unadjusted hazard ratios were 2.25 (95% CI, 1.66-3.06) and 1.55 (95% CI, 1.12-2.13), respectively. The corresponding fully adjusted hazard ratios were 1.47 (95% CI, 1.04-2.06) and 1.24 (95% CI, .91-1.70). CONCLUSIONS: Somatic symptoms of anxiety were robustly associated with an increased risk of CHD in women. This finding lends support to the physiological pathway for the association between psychological factors, anxiety in particular, and CHD.
机译：背景：尽管有证据表明焦虑是一种负面情绪，可能伴随着各种心理和躯体不适，但先前的研究很少将焦虑的这两个方面与冠心病（CHD）事件相关地考虑在内。这项研究旨在探讨焦虑的心理和躯体成分可预测冠心病的程度。方法：这是一项基于人群的前瞻性队列研究，研究对象为年龄在20至54岁之间的24,128名参与者（9830名男性，14,298名女性）。在1998年的研究基线时评估了心理和躯体症状。随后的7年中，致命的和非致命的CHD事件通过国家医院出院登记表的住院数据和芬兰统计局的死亡率记录得到记录。结果：在男性中，躯体症状的每单位平均得分升高的冠心病未经调整的危险比为1.50（95％置信区间[CI]，1.21-1.87），心理症状为1.04（95％CI，.85-1.29） 。在对社会人口统计学特征，生物行为危险因素和临床上显着的抑郁症状进行系列调整后，这些关联被完全消除。在女性中，相应的未经调整的危险比分别为2.25（95％CI，1.66-3.06）和1.55（95％CI，1.12-2.13）。相应的完全调整后的危险比是1.47（95％CI，1.04-2.06）和1.24（95％CI，.91-1.70）。结论：焦虑症的躯体症状与女性冠心病危险性增加密切相关。这一发现为心理因素，尤其是焦虑症与冠心病之间的关联的生理途径提供了支持。

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