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首页> 外文期刊>Biological psychiatry >Stress-related receptor targets for cocaine addiction.
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Stress-related receptor targets for cocaine addiction.

机译：可卡因成瘾的应激相关受体靶标。

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The last decade has witnessed the emergence of new pharmacotherapy in the treatment of drug and alcohol dependence, although addiction to the psychostimulants cocaine and amphetamines is notoriously resistant to pharmacological approaches that can effectively promote abstinence (1). Development of new. approaches to treatment that are derived from a deeper understanding of the pathogenesis of addiction is long overdue, but some evidence-based treatment strategies are promising. These treatments have relied, in part, on animal models capable of tracking changes in drug responsiveness after repeated exposure and more sophisticated animal models that capture the transition from initial drug use to a high degree of drug dependence. The neurobiological changes that accompany these behavioral changes are thought to enhance the motivation to self-administer drugs and alcohol and underlie the propensity for relapse over prolonged periods despite sincere efforts to abstain. Many of the neurobiological changes discovered using these animal models are common to multiple classes of abused drugs and alcohol, raising the exciting possibility that treatments designed to ameliorate these changes would have broad therapeutic impact in the treatment of addiction.
机译：过去十年见证了新的药物疗法在药物和酒精依赖治疗中的出现，尽管众所周知，对成瘾性精神兴奋剂可卡因和苯丙胺的成瘾对可以有效促进戒酒的药理方法具有抵抗力（1）。开发新的。对成瘾的发病机理有更深入的了解而产生的治疗方法早就该出现了，但是一些基于证据的治疗策略是有前途的。这些治疗在某种程度上依赖于能够追踪反复接触后药物反应性变化的动物模型，以及能够捕捉从最初的药物使用到高度药物依赖性的转变的更复杂的动物模型。这些行为改变所伴随的神经生物学改变被认为增强了自我管理药物和酒精的动机，并且尽管有诚意的弃权，但仍是长期复发的基础。使用这些动物模型发现的许多神经生物学变化是多种滥用药物和酒精所共有的，这令人振奋的可能性是，旨在缓解这些变化的治疗方法对成瘾的治疗具有广泛的治疗作用。

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