Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk

Cannon Tyrone D.; Chung Yoonho; He George; Sun Daqiang; Jacobson Aron; van Erp Theo G. M.; McEwen Sarah; Addington Jean; Bearden Carrie E.; Cadenhead Kristin; Cornblatt Barbara; Mathalon Daniel H.; McGlashan Thomas; Perkins Diana; Jeffries Clark; Seidman Larry J.; Tsuang Ming; Walker Elaine; Woods Scott W.; Heinssen Robert

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Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk

机译：随着精神病的发展逐渐降低皮质厚度：临床风险升高的青年人的多位点纵向神经影像研究

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BACKGROUND: Individuals at clinical high risk (CHR) who progress to fully psychotic symptoms have been observed to show a steeper rate of cortical gray matter reduction compared with individuals without symptomatic progression and with healthy control subjects. Whether such changes reflect processes associated with the pathophysiology of schizophrenia or exposure to antipsychotic drugs is unknown.

机译：背景：与无症状进展的个体和健康对照者相比，已发展为完全精神病性症状的临床高危（CHR）个体显示出皮层灰质减少的速率更高。这种变化是否反映了精神分裂症的病理生理过程或接触抗精神病药的过程尚不清楚。

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《Biological psychiatry》 |2015年第2期|共11页
作者
Cannon Tyrone D.; Chung Yoonho; He George; Sun Daqiang; Jacobson Aron; van Erp Theo G. M.; McEwen Sarah; Addington Jean; Bearden Carrie E.; Cadenhead Kristin; Cornblatt Barbara; Mathalon Daniel H.; McGlashan Thomas; Perkins Diana; Jeffries Clark; Seidman Larry J.; Tsuang Ming; Walker Elaine; Woods Scott W.; Heinssen Robert;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Inflammation; MRI; Prefrontal cortex; Prodromal; Psychosis; Schizophrenia;

机译：炎症;核磁共振;前额叶皮层;前驱;精神病;精神分裂症;

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1. Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk [J] . Cannon Tyrone D., Chung Yoonho, He George, Biological psychiatry . 2015,第2期

机译：随着精神病的发展逐渐降低皮质厚度：临床风险升高的青年人的多位点纵向神经影像研究
2. Reliability of neuroanatomical measurements in a multisite longitudinal study of youth at risk for psychosis [J] . CannonT.D., SunF., McewenS.J., Human brain mapping . 2014,第5期

机译：神经解剖学测量在多发性纵向研究中的可靠性
3. Correction: Progressive decline in hippocampal CA1 volume in individuals at ultra-high-risk for psychosis who do not remit: findings from the longitudinal youth at risk study [J] . New Fei Ho, Daphne J. Holt, Mike Cheung, Neuropsychopharmacology . 2019,第12期

机译：校正：高度轻度精神病患者中未缓解的海马CA1量逐渐下降：纵向青年处于风险研究中
4. Consistent 4D Cortical Thickness Measurement for Longitudinal Neuroimaging Study [C] . Yang Li, Yaping Wang, Zhong Xue, International conference on medical image computing and computer-assisted intervention;MICCAI 2010 . 2010

机译：纵向神经成像研究的一致4D皮质厚度测量
5. Movement Abnormalities, Frontal-Subcortical Structure and Function in Youth at Clinical High Risk for Psychosis [D] . Dean, Derek James. 2019

机译：运动异常，额外的细胞结构和青少年功能在精神病症的临床高风险下
6. Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk [O] . Tyrone D. Cannon, Yoonho Chung, George He, -1

机译：随着精神病的发展皮质厚度逐渐降低：临床风险升高的青年人的多位点纵向神经影像研究
7. Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk [O] . Tyrone D. Cannon, Yoonho Chung, George He, 2015

机译：皮质厚度作为精神病发展的渐进式减少：临床风险提高的青少年多高纵向神经影像研究

Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk

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