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Improving Response Inhibition in Parkinson's Disease with Atomoxetine

机译:用阿托莫西汀改善帕金森氏病的反应抑制

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BACKGROUND: Dopaminergic drugs remain the mainstay of Parkinson's disease therapy but often fail to improve cognitive problems such as impulsivity. This may be due to the loss of other neurotransmitters, including noradrenaline, which is linked to impulsivity and response inhibition. We therefore examined the effect of the selective noradrenaline reuptake inhibitor atomoxetine on response inhibition in a stop-signal paradigm.
机译:背景:多巴胺能药物仍然是帕金森氏病治疗的主要手段,但常常无法改善冲动等认知问题。这可能是由于其他神经递质的损失,包括去甲肾上腺素,与冲动性和反应抑制有关。因此,我们研究了停止信号范式中选择性去甲肾上腺素再摄取抑制剂托莫西汀对反应抑制的影响。

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