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Brain Rhythms Connect Impaired Inhibition to Altered Cognition in Schizophrenia

机译:脑节律将精神分裂症的抑制抑制与认知改变联系起来

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摘要

In recent years, schizophrenia research has focused on inhibitory interneuron dysfunction at the level of neurobiology and on cognitive impairments at the psychological level. Reviewing both experimental and computational findings, we show how the temporal structure of the activity of neuronal populations, exemplified by brain rhythms, can begin to bridge these levels of complexity. Oscillations in neuronal activity tie the pathophysiology of schizophrenia to alterations in local processing and large-scale coordination, and these alterations in turn can lead to the cognitive and perceptual disturbances observed in schizophrenia.
机译:近年来,精神分裂症的研究集中在神经生物学水平的抑制性神经元间功能障碍和心理水平的认知障碍上。回顾实验和计算结果,我们表明神经元活动的时间结构如何以脑节律为例,可以开始弥合这些复杂性水平。神经元活动的振荡将精神分裂症的病理生理与局部加工和大规模协调的改变联系起来,而这些改变又可导致在精神分裂症中观察到的认知和知觉障碍。

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