Heritability of Subcortical and Limbic Brain Volume and Shape in Multiplex-Multigenerational Families with Schizophrenia

Roalf David R.; Vandekar Simon N.; Almasy Laura; Ruparel Kosha; Satterthwaite Theodore D.; Elliott Mark A.; Podell Jamie; Gallagher Sean; Jackson Chad T.; Prasad Konasale; Wood Joel; Pogue-Geile Michael F.; Nimgaonkar Vishwajit L.; Gur Ruben C.; Gur Raquel E.

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Heritability of Subcortical and Limbic Brain Volume and Shape in Multiplex-Multigenerational Families with Schizophrenia

机译：多个多代精神分裂症家庭皮下和边缘大脑体积和形状的遗传力。

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BACKGROUND: Brain abnormalities of subcortical and limbic nuclei are common in patients with schizophrenia, and variation in these structures is considered a putative endophenotype for the disorder. Multiplex-multigenerational families with schizophrenia provide an opportunity to investigate the impact of shared genetic ancestry, but these families have not been previously examined to study structural brain abnormalities. We estimate the heritability of subcortical and hippocampal brain volumes in multiplex-multigenerational families and the heritability of subregions using advanced shape analysis.

机译：背景：精神分裂症患者常见皮层下和边缘核的大脑异常，这些结构的变化被认为是该疾病的推测内表型。患有精神分裂症的多代-多代家庭为研究共享遗传祖先的影响提供了机会，但是这些家庭以前没有经过研究以研究脑结构异常。我们使用先进的形状分析方法估算了多重多代家族中皮层下和海马脑体积的遗传力，以及亚区域的遗传力。

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《Biological psychiatry》 |2015年第2期|共10页
作者
Roalf David R.; Vandekar Simon N.; Almasy Laura; Ruparel Kosha; Satterthwaite Theodore D.; Elliott Mark A.; Podell Jamie; Gallagher Sean; Jackson Chad T.; Prasad Konasale; Wood Joel; Pogue-Geile Michael F.; Nimgaonkar Vishwajit L.; Gur Ruben C.; Gur Raquel E.;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Endophenotypes; Heritability; Hippocampus; Neuroimaging-genetics; Schizophrenia; Structural MRI;

机译：内表型;遗传性;海马体;神经影像遗传学;精神分裂症;结构核磁共振;

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1. Heritability of Subcortical and Limbic Brain Volume and Shape in Multiplex-Multigenerational Families with Schizophrenia [J] . Roalf David R., Vandekar Simon N., Almasy Laura, Biological psychiatry . 2015,第2期

机译：多个多代精神分裂症家庭皮下和边缘大脑体积和形状的遗传力。
2. Heritability of the shape of subcortical brain structures in the general population [J] . Gennady V. Roshchupkin, Boris A. Gutman, Meike W. Vernooij, Nature Communications . 2016,第1期

机译：普通人群皮层下大脑结构形状的遗传力
3. Development and heritability of subcortical brain volumes at ages 9 and 12 [J] . Swagerman S. C., Brouwer R. M., de Geus E. J. C., Genes, brain, and behavior . 2014,第8期

机译：9岁和12岁时皮层下大脑体积的发育和遗传性
4. Comparison of volumes of subcortical regions in schizophrenia patients and healthy controls using MRI [C] . Khodaei Afsoon, Hossein-Zadeh Gholam-Ali, Ananloo Esmaeil Shahsavand International Conference on Pattern Recognition and Image Analysis . 2015

机译：精神分裂症患者和健康对照者的MRI皮质下区域的体积比较
5. Functional and structural brain markers of the genetic vulnerability to schizophrenia: A neuroimaging investigation of schizophrenia patients, non -psychotic adult relatives, and community ontrols. [D] . Goghari, Vina Mahesh. 2009

机译：精神分裂症遗传易感性的功能性和结构性脑标志物：对精神分裂症患者，非精神病成年亲属和社区存在的神经影像学调查。
6. Heritability of Subcortical and Limbic Brain Volume and Shape in Multiplex-Multigenerational Families with Schizophrenia [O] . David R. Roalf, Simon N. Vandekar, Laura Almasy, -1

机译：多个多代精神分裂症家庭的皮层和下肢大脑体积和形状的遗传力
7. Heritability of the shape of subcortical brain structures in the general population [O] . Roshchupkin, Gennady V., Gutman, Boris A., Vernooij, Meike W., 2016

机译：一般人群皮层下大脑结构形状的遗传力

Heritability of Subcortical and Limbic Brain Volume and Shape in Multiplex-Multigenerational Families with Schizophrenia

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