• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Japanese Journal of Veterinary Research >Antigenic variation among equine H 3 N 8 influenza virus hemagglutinins.
【24h】

Antigenic variation among equine H 3 N 8 influenza virus hemagglutinins.

机译：马H 3 N 8流感病毒血凝素之间的抗原变异。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To provide information on the antigenic variation of the haemagglutinins (HA) among equine H 3 influenza viruses, 26 strains isolated from horses in different areas in the world during the 1963-1996 period were analysed using a panel of monoclonal antibodies recognizing at least 7 distinct epitopes on the H 3 HA molecule of the prototype strain A/equine/Miami/ 1 /63 (H 3 N 8). The reactivity patterns of the virus strains with the panel indicate that antigenic drift of the HA has occurred with the year of isolation, but less extensively than that of human H 3 N 2 influenza virus isolates, and different antigenic variants co-circulate. To assess immunogenicity of the viruses, antisera from mice vaccinated with each of the 7 representative inactivated viruses were examined by neutralization and haemagglutination-inhibition tests. These results emphasize the importance of monitoring the antigenic drift in equine influenza virus strains and to introduce current isolates into vaccine. On the basis of the present results, equine influenza vaccine strain A/equine/Tokyo/ 2 /71 (H 3 N 8) was replaced with A/equine/La Plata/ 1 /93 (H 3 N 8) in 1996 in Japan. The present results of the antigenic analysis of the 26 strains supported the results of a phylogenetic analysis, that viruses belonging to each of the Eurasian and American equine influenza lineages have independently evolved. However, the current vaccine in Japan consists of two American H 3 N 8 strains ; A/equine/Kentucky/ 1 /81 and A/equine/La Plata/ 1 /93. It is also therefore recommended that a representative Eurasian strain should be included as a replacement of A/equine/Kentucky/ 1 /81.
机译：为了提供有关马H 3流感病毒中血凝素（HA）抗原性变化的信息，使用一组识别至少7种不同抗体的单克隆抗体分析了1963-1996年期间从世界不同地区的马匹中分离出的26种菌株原型菌株A /马/迈阿密/迈阿密/ 1/63（H 3 N 8）的H 3 HA分子上的抗原决定簇。病毒株与小组的反应模式表明，随着分离年份的出现，HA的抗原漂移已经发生，但是其扩散程度不及人类H 3 N 2流感病毒分离株，并且不同的抗原变体共同传播。为了评估病毒的免疫原性，通过中和和血凝抑制试验检查了接种了7种代表性灭活病毒的小鼠的抗血清。这些结果强调了监测马流感病毒株中抗原漂移并将当前分离株引入疫苗的重要性。根据目前的结果，1996年在日本将马流感疫苗毒株A / equine / Tokyo / 2/71（H 3 N 8）替换为A / equine / La Plata / 1/93（H 3 N 8） 。对这26个菌株进行抗原分析的当前结果支持了系统发育分析的结果，即属于欧亚和美国马流感谱系的病毒均已独立进化。然而，日本目前的疫苗由两种美国的H 3 N 8株组成。 A /马/肯塔基/ 1/81和A /马/拉普拉塔/ 1/93。因此，还建议包括代表性的欧亚菌株，以替代A /马/肯塔基/ 1/81。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号