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首页> 外文期刊>The Japanese Journal of Veterinary Research >Passive immunization with monoclonal antibodies: effects on Haemaphysalis longicornis tick infestation of BALB/c mice
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Passive immunization with monoclonal antibodies: effects on Haemaphysalis longicornis tick infestation of BALB/c mice

机译：单克隆抗体的被动免疫：对BALB / c小鼠血红蛋白tick虱侵袭的影响

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摘要

Tick vaccine development plays an important role in current tick control strategies. Previously, we have produced three different isotypes of monoclonal antibodies (mAbs) which recognized a midgut protein of adult Haemaphysalis longicornis. These mAbs, typed as IgG1, 2a, and 2b, reacted with a 76 kDa surface protein of midgut cells. We speculated that the 76 kDa protein may be an unknown antigen for a tick vaccine and the three mAbs may work as probes to clone the protein. In this study, to test whether these three isotypes have antitick effects and if so which works more effectively, we conducted passive immunization in BALB/c mice with each of the mAbs, and infested the mice with adult ticks. All isotypes significantly reduced the number of hatched larvae, compared to controls, however, no differences in the magnitude of the reduction were observed among the three.
机译：壁虱疫苗的开发在当前的壁虱控制策略中起着重要作用。以前，我们已经产生了三种不同的同种型的单克隆抗体（mAbs），它们可以识别成年血吸虫的中肠蛋白。这些类型为IgG1、2a和2b的mAb与中肠细胞的76 kDa表面蛋白反应。我们推测76 kDa蛋白可能是壁虱疫苗的未知抗原，并且三个mAb可能充当克隆该蛋白的探针。在这项研究中，为了测试这三种同种型是否具有抗t虫作用，以及是否能更有效地起作用，我们对每种mAb的BALB / c小鼠进行了被动免疫，并用成年s虫感染了小鼠。与对照相比，所有同种型均显着减少了孵化幼虫的数量，但是，在这三种之间，未观察到减少幅度的差异。

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