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首页> 外文期刊>The Journal of clinical dentistry. >The effect of zinc acetate and magnolia bark extract added to chewing gum on volatile sulfur-containing compounds in the oral cavity
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The effect of zinc acetate and magnolia bark extract added to chewing gum on volatile sulfur-containing compounds in the oral cavity

机译：口香糖中添加醋酸锌和木兰皮提取物对口腔中挥发性含硫化合物的影响

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Objective: A controlled, clinical, double-blind study was conducted to assess the efficacy of a sugar-free chewing gum containing zinc acetate and magnolia bark extract (MBE) on oral volatile sulfur-containing compounds (VSC) versus a placebo sugar-free chewing gum for two hours. Methods: To participate in the study, subjects had to have at least 24 of their teeth, no report of oral and systemic diseases, and no removable dentures. All 168 eligible participants had to avoid any professional oral hygiene, refrain from taking medicine for two weeks, and not be menstruating. They were also instructed not to brush their teeth and tongue, smoke, drink alcohol, or eat onion, garlic, or licorice for the six-hour period before the visit and during the test. Moreover, to join the protocol, they had to show a VSC score of > 75 ppb at the baseline measurement. One-hundred and twenty-three subjects (67 men and 56 women, mean age 37) met the criteria at baseline and were entered into either the test or control group by assignment from a table of randomized numbers. The test chewing gum (2.23 g) contained zinc acetate 0.012% and magnolia bark extract 0.15% in weight; the control gum was equivalent without these active agents. The OralChroma? device was utilized to evaluate total oral VSC. Their levels were recorded at baseline, after ten minutes of mastication, after one hour, and after two hours. Data were analyzed with SPSS software and the level of significance was set at a = 0.05. Results: One-hundred and twenty-three subjects completed the trial (62 in the control group and 61 in the test group); none reported problems linked to zinc acetate or magnolia bark extract. The mean percentage reductions from baseline at the end of the 10-minute chewing were 31.2% in the control group (p < 0.05) and 50.9% in the test group (p < 0.05). One hour later the reductions were 6.9% in the control group and 27.6% in the test group (p < 0.05); two hours later the reductions were 2.3% in the control group and 13.6% in the test group. The comparison of the two groups after baseline adjustment showed a statistically significant difference (p < 0.05) in VSC reductions between the test and control chewing gums at the end of the mastication period and after one hour. Conclusion: Chewing gum containing zinc acetate and magnolia bark extract can significantly reduce the oral VSC levels for more than one hour. Moreover, the test chewing gum reduces oral VSC significantly more than a control chewing gum.
机译：目的：进行了一项对照，临床，双盲研究，以评估含醋酸锌和木兰皮提取物（MBE）的无糖口香糖对口服挥发性含硫化合物（VSC）与无糖安慰剂的疗效。嚼口香糖两个小时。方法：要参加该研究，受试者必须至少有24颗牙齿，没有口腔和全身疾病的报道，也没有可移动的假牙。所有168名符合条件的参与者都必须避免任何专业的口腔卫生，不要吃药两周，而且不要月经。还要求他们在探视前和测试期间的六个小时内不要刷牙和舌头，抽烟，喝酒或吃洋葱，大蒜或甘草。此外，要加入该协议，他们必须在基线测量时显示VSC得分> 75 ppb。一百二十三名受试者（67名男性和56名女性，平均年龄37岁）符合基线标准，并通过分配随机数字表进入测试组或对照组。测试的口香糖（2.23g）含有0.012％重量的乙酸锌和0.15％重量的木兰皮提取物。没有这些活性剂的对照胶是等效的。口腔色瘤？该装置被用于评估总的口服VSC。在基线时，咀嚼十分钟后，一小时后和两小时后记录其水平。使用SPSS软件分析数据，并将显着性水平设置为a = 0.05。结果：一百二十三名受试者完成了试验（对照组为62名，试验组为61名）。没有人报告与醋酸锌或木兰皮提取物有关的问题。咀嚼10分钟后与基线相比的平均减少百分比在对照组中为31.2％（p <0.05），在测试组中为50.9％（p <0.05）。一小时后，对照组减少6.9％，测试组减少27.6％（p <0.05）;两小时后，对照组的减少量为2.3％，测试组的减少量为13.6％。基线调整后两组的比较显示，咀嚼期结束时和一小时后，测试和对照组口香糖之间的VSC减少量具有统计学上的显着差异（p <0.05）。结论：含醋酸锌和木兰皮提取物的口香糖可以显着降低口腔中VSC含量超过一小时。此外，与对照口香糖相比，测试口香糖可显着降低口服VSC。

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