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首页> 外文期刊>The journal of clinical hypertension. >Peripheral and central blood pressure responses of combination aliskiren/hydrochlorothiazide and amlodipine monotherapy in African American patients with stage 2 hypertension: the ATLAAST trial.
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Peripheral and central blood pressure responses of combination aliskiren/hydrochlorothiazide and amlodipine monotherapy in African American patients with stage 2 hypertension: the ATLAAST trial.

机译：阿利吉仑/氢氯噻嗪联合氨氯地平单药治疗2期非裔美国人的外周和中心血压反应：ATLAAST试验。

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摘要

Efficacy of antihypertensive agents on central blood pressure (BP) in African Americans is not well studied. The authors report on an 8-week double-blind, randomized study of African American patients with stage 2 hypertension that compared brachial and central BP responses (substudy of 53 patients) to combination aliskiren/hydrochlorthiazide (HCTZ) and amlodipine monotherapy. Following a 1- to 4-week washout, initial therapy was aliskiren/HCTZ 150/12.5 mg (n=166) or amlodipine 5 mg (n=166) for 1 week, forced-titrated to aliskiren/HCTZ 300/25 mg or amlodipine 10 mg for 7 weeks. Mean seated systolic BP reductions from baseline was similar with both treatments (-28.6 mm Hg with aliskiren/HCTZ vs -28.2 mm Hg with amlodipine). In the substudy, significantly greater reductions in central systolic BP was observed with aliskiren/HCTZ vs amlodipine (-30.1 mm Hg vs -21.2; P=.031), although 24-hour mean ambulatory BP reductions between the two groups were similar. Central pressure is considered an important risk factor in African Americans, and these findings may suggest a new treatment option for these patients.
机译：抗高血压药对非裔美国人的中央血压（BP）的功效尚未得到很好的研究。作者报告了一项为期8周的针对2期高血压的非洲裔美国人的双盲，随机研究，该研究比较了阿里斯基仑/氢氯噻嗪（HCTZ）和氨氯地平单药联合治疗的肱臂和中枢BP反应（53例患者的研究）。冲洗1至4周后，初始治疗为aliskiren / HCTZ 150 / 12.5 mg（n = 166）或氨氯地平5 mg（n = 166）1周，然后用力滴定至aliskiren / HCTZ 300/25 mg或氨氯地平10毫克，持续7周。两种治疗方法相比基线的平均坐位收缩压降低幅度相似（阿利吉仑/ HCTZ组为-28.6 mm Hg，氨氯地平组为-28.2 mm Hg）。在亚组研究中，阿利吉仑/ HCTZ组与氨氯地平组相比，氨氯地平观察到的中央收缩期BP明显降低（-30.1 mm Hg vs -21.2; P = .031），尽管两组之间的24小时平均动态血压降低相似。在非裔美国人中，中央压力被认为是重要的危险因素，这些发现可能为这些患者提出了新的治疗选择。

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