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首页> 外文期刊>The journal of clinical hypertension. >Severity of Peripheral Arterial Disease is Associated With Aortic Pressure Augmentation and Subendocardial Viability Ratio
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Severity of Peripheral Arterial Disease is Associated With Aortic Pressure Augmentation and Subendocardial Viability Ratio

机译：周围动脉疾病的严重程度与主动脉压增高和心内膜下存活率有关

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Peripheral arterial disease (PAD) is associated with increased cardiovascular mortality that correlates with peripheral perfusion impairment as assessed by the ankle-brachial arterial pressure index (ABI). Furthermore, PAD is associated with arterial stiffness and elevated aortic augmentation index (AIx). The purpose of this study was to investigate whether ABI impairment correlates with AIx and subendocardial viability ratio (SEVR), a measure of cardiac perfusion during diastole. AIx and SEVR were assessed by radial applanation tonometry in 65 patients with stable PAD (Rutherford stage IIII) at a tertiary referral center. AIx corrected for heart rate and SEVR were tested in a multivariate linear and logistic regression model to determine the association with ABI. Mean ABI was 0.8 +/- 0.2, AIx 31%+/- 7%, and SEVR 141%+/- 26%. Multiple linear regression with AIx as a dependent variable revealed that AIx was significantly negatively associated with ABI (beta=-11.5; 95% confidence interval [CI], -18.6 to -4.5; P=.002). Other variables that were associated with AIx were diastolic blood pressure (beta=0.2; 95% CI, 0.10.4; P<.001), height (beta=-46.2; 95% CI, -62.9 to -29.4; P<.001), body mass index (beta=-0.4; 95% CI, -0.8 to -0.1; P=.023), and smoking (beta=3.6; 95% CI, 0.66.6; P=.019). Multiple regression with SEVR as a dependent variable showed a significant correlation with ABI (beta=33.2; 95% CI, 2.364.1; P=.036). Severity of lower limb perfusion impairment is related to central aortic pressure augmentation and to subendocardial viability ratio. This may be a potential pathophysiologic link that impacts cardiac prognosis in patients with PAD. J Clin Hypertens (Greenwich). 2012; 14:855860. (c) 2012 Wiley Periodicals, Inc.
机译：外周动脉疾病（PAD）与心血管疾病死亡率增加相关，心血管疾病死亡率与通过踝臂肱动脉压力指数（ABI）评估的外周血灌注障碍相关。此外，PAD与动脉僵硬度和主动脉扩张指数（AIx）升高相关。这项研究的目的是调查ABI损伤是否与AIx和心内膜下生存率（SEVR）相关，后者是舒张期心脏灌注的一种指标。在三级转诊中心，对65例稳定型PAD（卢瑟福IIII期）患者进行放射状扁平压术评估AIx和SEVR。在多元线性和逻辑回归模型中测试校正了心率的AIx和SEVR，以确定与ABI的关联。平均ABI为0.8 +/- 0.2，AIx 31％+ /-7％和SEVR 141％+ /-26％。以AIx为因变量的多元线性回归显示，AIx与ABI显着负相关（β= -11.5; 95％置信区间[CI]，-18.6至-4.5; P = .002）。与AIx相关的其他变量是舒张压（beta = 0.2; 95％CI，0.10.4; P <.001），身高（beta = -46.2; 95％CI，-62.9至-29.4; P <。 001），体重指数（β= -0.4; 95％CI，-0.8至-0.1; P = .023）和吸烟（β= 3.6; 95％CI，0.66.6; P = .019）。以SEVR作为因变量的多元回归显示与ABI显着相关（β= 33.2; 95％CI，2.364.1; P = .036）。下肢灌注障碍的严重程度与中央主动脉压力增加和心内膜下生存力比率有关。这可能是影响PAD患者心脏预后的潜在病理生理联系。 J临床高血压（格林威治）。 2012; 14：855860。 （c）2012年威利期刊有限公司

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