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首页> 外文期刊>The journal of clinical hypertension. >Carvedilol-lisinopril combination therapy and endothelial function in obese individuals with hypertension
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Carvedilol-lisinopril combination therapy and endothelial function in obese individuals with hypertension

机译：卡维地洛-赖诺普利联合治疗与肥胖高血压患者的内皮功能

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The authors hypothesized that carvedilol controlled-release plus lisinopril combination therapy (C+L) would increase endothelial function and decrease oxidative stress to a greater extent than hydrochlorothiazide plus lisinopril combination therapy (H+L) in obese patients with hypertension. Twenty-five abdominally obese patients (aged 54.4±7.3 years; 14 women) with hypertension/prehypertension were enrolled in a 7-month (two 3-month treatment periods separated by a 1-month washout), randomized, double-blind, controlled, crossover clinical trial comparing C+L vs H+L. Endothelial function, measured by digital reactive hyperemic index (RHI), circulating oxidized low-density lipoprotein (oxLDL), 8-isoprostane, and asymmetric dimethylarginine (ADMA) were obtained at baseline, post-period 1, post-washout, and post-period 2. Analyses were adjusted for baseline measurements by analysis of covariance, with robust variance estimation for confidence intervals and P values. C+L treatment compared to H+L treatment significantly improved RHI (0.74, 95% confidence interval, 0.31-1.19, P=.001). This difference persisted after adjustment for the change in systolic blood pressure. No significant treatment differences were observed for oxLDL, 8-isoprostane, or ADMA. These data provide evidence that independent of blood pressure-lowering, C+L therapy improves endothelial function to a greater extent than H+L therapy. Levels of oxidative stress were not significantly different between treatments, suggesting that other mechanisms may be responsible for the improvement in endothelial function.
机译：作者假设卡维地洛控释加赖诺普利联合治疗（C + L）在肥胖的高血压患者中比氢氯噻嗪加赖诺普利联合治疗（H + L）在更大程度上增加内皮功能并降低氧化应激。 25名患有高血压/高血压前期的腹部肥胖患者（年龄54.4±7.3岁; 14名女性）参加了为期7个月（两个3个月的治疗期，每个治疗期为1个月的冲洗）的随机，双盲，对照研究，这是一项比较C + L与H + L的交叉临床试验。在基线，周期1，洗脱后和冲洗后，通过数字反应性充血指数（RHI），循环氧化的低密度脂蛋白（oxLDL），8-异前列腺素和不对称二甲基精氨酸（ADMA）来测量内皮功能。第2阶段。通过协方差分析对基线测量进行分析调整，并对置信区间和P值进行稳健的方差估计。与H + L治疗相比，C + L治疗显着改善RHI（0.74，95％置信区间，0.31-1.19，P = .001）。调整收缩压后，这种差异仍然存在。对于oxLDL，8-异前列腺素或ADMA，未观察到明显的治疗差异。这些数据提供了证据，与H + L治疗相比，与降压无关，C + L治疗在很大程度上改善了内皮功能。两种治疗方法之间的氧化应激水平无明显差异，表明其他机制可能是内皮功能改善的原因。

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