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首页> 外文期刊>The journal of clinical hypertension. >Overlapping Spironolactone Dosing in Primary Aldosteronism and Resistant Essential Hypertension
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Overlapping Spironolactone Dosing in Primary Aldosteronism and Resistant Essential Hypertension

机译：重叠螺内酯加药治疗原发性醛固酮增多症和抵抗性原发性高血压

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摘要

A 65-year-old man presented to our hypertension clinic with refractory hypertension and hypokalemia. At age 11 he was beaten up, suffering a left renal injury that required hospitalization. Subsequent dia-stolic blood pressures (BPs) rose to 105 mm Hg throughout high school and into college, gradually resolving off of medication. He had been treated with antihypertensive therapy for more than 25 years with poor control. Amlodipine and nifedipine were not tolerated due to edema. Hypokalemia was noted and prior to spironolactone initiation, the patient required 100 mEq of potassium replacement daily. On spironolactone 25 mg, potassium was reduced to 40 mEq daily. A daughter of the patient, age 20, was being treated for hypertension, but there was no family history of stroke or myocardial infarction.
机译：一名65岁的男子因难治性高血压和低钾血症出现在我们的高血压诊所。他在11岁时遭到殴打，左肾受伤，需要住院治疗。在整个高中和大学期间，随后的透析压力（BPs）上升至105 mm Hg，逐渐消除了用药。他接受了降压治疗超过25年，控制不佳。由于水肿，不能耐受氨氯地平和硝苯地平。注意到低钾血症，在开始螺内酯之前，患者每天需补充100 mEq的钾。服用25 mg螺内酯后，每天将钾减少至40 mEq。患者的一名20岁女儿正在接受高血压治疗，但没有中风或心肌梗塞家族史。

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