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Cyclophosphamide-Induced Hypertensive Encephalopathy in a Young Girl With Lupus

机译:环磷酰胺诱发的年轻女孩狼疮性高血压脑病

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To the Editor:Despite potential toxic effects including bone marrow suppression, hemorrhagic cystitis, opportunistic infections, malignant diseases, and premature gonadal failure, intravenous cyclophosphamide is still regarded as the standard of care for treating severe systemic lupus erythematosus (SLE) in developing countries.1 Hypertensive encephalopathy is seldom induced by cyclophosphamide in lupus patients. According to the data of eHealthMe, 28,434 people reported to have side effects when taking cyclophosphamide; among them, only 13 people (0.05%) experienced hypertensive encephalopathy. In the present report, we describe an unusual case of hypertensive encephalopathy in a young girl undergoing her first induction therapy with cyclophosphamide for active SLE.
机译:致编辑者:尽管潜在的毒性作用包括抑制骨髓,出血性膀胱炎,机会性感染,恶性疾病和性腺早衰,但静脉环磷酰胺仍被视为发展中国家治疗严重系统性红斑狼疮(SLE)的治疗标准。 1环磷酰胺在狼疮患者中很少诱发高血压性脑病。根据eHealthMe的数据,有28,434人报告服用环磷酰胺有副作用。其中只有13人(0.05%)患有高血压性脑病。在本报告中,我们描述了一名年轻女孩在首次接受环磷酰胺诱导疗法治疗活动性SLE的情况下发生高血压脑病的罕见情况。

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