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首页> 外文期刊>The journal of clinical hypertension. >A hypertensive response to exercise is prominent in patients with obstructive sleep apnea and hypertension: A controlled study
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A hypertensive response to exercise is prominent in patients with obstructive sleep apnea and hypertension: A controlled study

机译：阻塞性睡眠呼吸暂停和高血压患者对运动的高血压反应突出：一项对照研究

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Blood pressure (BP) behavior during exercise is not clear in hypertensive patients with obstructive sleep apnea (OSA). The authors studied 57 men with newly diagnosed essential hypertension and untreated OSA (apnea-hypopnea index [AHI] ≥5) but without daytime sleepiness (Epworth Sleepiness Scale score ≤10), and an equal number of hypertensive controls without OSA matched for age, body mass index, and office systolic BP. All patients underwent ambulatory BP measurements, transthoracic echocardiography, and exercise treadmill testing according to the Bruce protocol. A hypertensive response to exercise (HRE) was defined as peak systolic BP ≥210 mm Hg. Patients with OSA and control patients had similar ambulatory and resting BP, ejection fraction, and left ventricular mass. Peak systolic BP was significantly higher in patients with OSA (197.6±25.6 mm Hg vs 187.8±23.6 mm Hg; P=03), while peak diastolic BP and heart rate did not differ between groups. Furthermore, an HRE was more prevalent in patients with OSA (44% vs 19%; P=009). Multiple logistic regression revealed that an HRE is independently predicted by both the logAHI and minimum oxygen saturation during sleep (odds ratio, 3.94; confidence interval, 1.69-9.18; P=001 and odds ratio, 0.94; confidence interval, 0.89-0.99; P=02, respectively). Exaggerated BP response is more prevalent in nonsleepy hypertensives with OSA compared with their nonapneic counterparts. This finding may have distinct diagnostic and prognostic implications.
机译：阻塞性睡眠呼吸暂停（OSA）的高血压患者运动期间的血压（BP）行为尚不清楚。作者研究了57例新诊断为原发性高血压且未经治疗的OSA（呼吸暂停-低通气指数[AHI]≥5）但无白天嗜睡（Epworth嗜睡量表评分≤10），以及相等年龄的无OSA的高血压对照患者，体重指数和办公室收缩压。所有患者均按照Bruce规程进行动态BP测量，经胸超声心动图检查和运动跑步机测试。运动的高血压反应（HRE）被定义为收缩压峰值BP≥210mm Hg。 OSA患者和对照组患者的门诊和静息血压，射血分数和左心室质量相似。 OSA患者的收缩压峰值显着较高（197.6±25.6 mm Hg与187.8±23.6 mm Hg; P = 03），而两组之间的舒张压峰值和心率无差异。此外，HRE在OSA患者中更为普遍（44％比19％; P = 009）。多元logistic回归分析显示，HRE由logAHI和睡眠期间的最低氧饱和度独立预测（几率3.94;置信区间1.69-9.18; P = 001，优势比0.94;置信区间0.89-0.99; P分别为= 02）。与非窒息性高血压患者相比，OSA非嗜睡性高血压患者的BP反应更为普遍。这一发现可能具有独特的诊断和预后意义。

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