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首页> 外文期刊>The journal of clinical hypertension. >Masked hypertension defined by home blood pressure monitoring is associated with impaired flow-mediated vasodilatation in patients with cardiovascular risk factors
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Masked hypertension defined by home blood pressure monitoring is associated with impaired flow-mediated vasodilatation in patients with cardiovascular risk factors

机译：由家庭血压监测定义的掩盖性高血压与心血管危险因素患者的血流介导的血管舒张受损有关

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The relationships between home blood pressure (BP), masked hypertension defined by home BP, and integrated flow-mediated vasodilation (FMD) response remain unclear. The authors enrolled 257 patients (mean age, 63.5 years; 51% men) who had at least one cardiovascular risk factor. FMD of the brachial artery was measured with a semiautomatic edge-detection algorithm. The integrated FMD response was calculated as the area under the dilation curve during 120 seconds after deflation (FMD-AUC120) and the FMD magnitude as the percentage change in peak diameter (ΔFMD). Masked hypertension was defined by office BP 140/90 mm Hg and home BP ≥135 mm Hg and/or 85 mm Hg. Home systolic BP was inversely correlated with FMD-AUC120 and ΔFMD (FMD-AUC120: r=-23, P .001; ΔFMD: r=-13, P=041), and office systolic BP was inversely associated with FMD-AUC120 (r=-16, P=011), but not with ΔFMD. After adjusting for covariates, home systolic BP (β=-27, P=003), but not office BP, was inversely associated with FMD-AUC120, whereas ΔFMD was not associated with office or home systolic BP. FMD-AUC120 was significantly lower in patients with masked hypertension compared with those with normotension (7.7±6.7 vs 11.5±8.8 mm × s, P=048). Home systolic BP and masked hypertension defined by home BP were associated with a decrease in FMD-AUC120.
机译：尚不清楚家庭血压（BP），由家庭BP定义的掩盖性高血压和整合的血流介导的血管舒张（FMD）反应之间的关系。作者纳入了至少有一种心血管危险因素的257名患者（平均年龄63.5岁;男性51％）。用半自动边缘检测算法测量肱动脉的口蹄疫。积分的FMD响应计算为放气后120秒内膨胀曲线下的面积（FMD-AUC120），FMD量值作为峰直径的百分比变化（ΔFMD）。掩盖性高血压定义为办公室BP <140/90 mm Hg和家庭BP≥135mm Hg和/或85 mm Hg。家庭收缩压与FMD-AUC120和ΔFMD呈负相关（FMD-AUC120：r = -23，P <.001;ΔFMD：r = -13，P = 041），而办公室收缩压与FMD-AUC120呈负相关（r = -16，P = 011），但不使用ΔFMD。调整协变量后，家庭收缩压（β= -27，P = 003），而不是办公室BP与FMD-AUC120成反比，而ΔFMD与办公室或家庭收缩BP不相关。蒙面高血压患者的FMD-AUC120显着低于正常血压患者（7.7±6.7对11.5±8.8 mm×s，P = 048）。家庭收缩压和由家庭血压定义的掩盖性高血压与FMD-AUC120的降低有关。

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