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首页> 外文期刊>The journal of clinical hypertension. >Efficacy/Safety of a Fixed-Dose Amlodipine/Olmesartan Medoxomil-Based Treatment Regimen in Hypertensive Blacks and Non-Blacks With Uncontrolled BP on Prior Antihypertensive Monotherapy
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Efficacy/Safety of a Fixed-Dose Amlodipine/Olmesartan Medoxomil-Based Treatment Regimen in Hypertensive Blacks and Non-Blacks With Uncontrolled BP on Prior Antihypertensive Monotherapy

机译：固定剂量氨氯地平/奥美沙坦以美多西米为基础的高血压黑人和非黑人非控制性高血压患者在先前抗高血压单药治疗中的疗效/安全性

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摘要

In this secondary analysis of a dose-titration study of patients with hypertension uncontrolled on prior monotherapy, blacks (n=234) and non-blacks (n=765) were switched to amlodipine (AML)/olmesartan medoxomil (OM) 5/20 mg, with uptitration every 4 weeks to AML/OM 5/40 mg and then AML/OM 10/40 mg to achieve a seated cuff blood pressure (SeBP) of <120/70 mm Hg. Hydrochlorothiazide 12.5 and 25 mg could be added if SeBP was ≥125/75 mm Hg. The cumulative proportions of patients achieving systolic SeBP <140 mm Hg (<130 mm Hg if diabetic) at 12 weeks were 71.6% for blacks and 77.2% for non-blacks. Mean SeBP change from baseline in blacks (mean baseline BP: 153.0/93.7 mm Hg) ranged from -11.7/-6.1 mm Hg for AML/OM 5/20 mg to -23.6/-12.9 mm Hg for AML/OM 10/40 mg +hydrochlorothiazide 25 mg (all P<.0001). Antihypertensive efficacy was maintained throughout the 24-hour dosing interval. An AML/OM-based regimen was effective in blacks with hypertension uncontrolled on prior monotherapy.
机译：在对先前单药治疗无法控制的高血压患者进行剂量滴定研究的二级分析中，黑人（n = 234）和非黑人（n = 765）被改用氨氯地平（AML）/奥美沙坦美多西米（OM）5/20 ，每4周增加AML / OM 5/40毫克，然后AML / OM 10/40毫克，以达到<120/70 mm Hg的就诊袖带血压（SeBP）。如果SeBP≥125/ 75 mm Hg，则可以添加12.5和25 mg氢氯噻嗪。黑人在12周时达到收缩压SeBP <140 mm Hg（如果患有糖尿病，则<130 mm Hg）的累积比例，黑人为71.6％，非黑人为77.2％。黑人的平均SeBP从基线的平均变化（平均基线BP：153.0 / 93.7 mm Hg）从AML / OM 5/20 mg的-11.7 / -6.1 mm Hg到AML / OM 10/40的-23.6 / -12.9 mm Hg毫克+氢氯噻嗪25毫克（所有P <.0001）。在整个24小时的给药间隔中均保持降压功效。基于AML / OM的治疗方案对先前单一疗法无法控制的高血压黑人有效。

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