Diastereoselective synthesis of some carbocyclic 2′-oxa-3′-aza-nucleosides

E. Hyrosova; L. Fisera; R. M.-A. Jame; N. Pronayova; M. Medveckiy; M. Koos

首页> 外文期刊>Chemistry of heterocyclic compounds >Diastereoselective synthesis of some carbocyclic 2′-oxa-3′-aza-nucleosides

【24h】

Diastereoselective synthesis of some carbocyclic 2′-oxa-3′-aza-nucleosides

机译：一些碳环2'-oxa-3'-氮杂-核苷的非对映选择性合成

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Two strategies for the synthesis of isoxazolidinyl nucleosides as potential antiviral agents are reported: a one-step approach based on 1,3-dipolar cycloaddition of D-lyxosyl nitrone with N,N-dibenzyl-9-vinyl adenine, and a two-step methodology based on the Vorbrüggen nucleosidation of the 5-acetoxyisoxazolidine. The chiral D-lyxosyl nitrone undergoes regioselective 1,3-dipolar cycloadditions with N,N-dibenzyl-9-vinyl adenine and vinyl acetate giving 5-substituted isoxazolidines as a mixture of four diastereoisomers in good yields. The condensation of 5-acetoxyisoxazolidine with silylated uracil, thymine, and N-acetylcytosine proceeded with moderate to good stereoselectivity with the formation of the expected isoxazolidinyl β-and α-nucleosides.

机译：据报道，有两种合成异恶唑啉基核苷作为潜在抗病毒剂的策略：一种基于D-糖基硝酮与N，N-二苄基-9-乙烯基腺嘌呤的1,3-偶极环加成的一步法，以及一种两步法的方法基于5-乙酰氧基异唑烷的Vorbrüggen核苷化。手性D-二糖基硝酮与N，N-二苄基-9-乙烯基腺嘌呤和乙酸乙烯酯进行区域选择性的1,3-偶极环加成反应，以高收率得到5-取代的异恶唑烷，为四种非对映异构体的混合物。 5-乙酰氧基异恶唑烷与甲硅烷基化的尿嘧啶，胸腺嘧啶和N-乙酰胞嘧啶的缩合以中等至良好的立体选择性进行，形成了预期的异恶唑烷酰基β-和α-核苷。

著录项

来源
《Chemistry of heterocyclic compounds》 |2007年第1期|共8页
作者
E. Hyrosova; L. Fisera; R. M.-A. Jame; N. Pronayova; M. Medveckiy; M. Koos;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类杂环化合物;
关键词
chiral; dipolar cycloadditions; isoxazolidines; modified nucleosides; nitrones;

机译：手性;偶极环加成;异恶唑烷;修饰的核苷;硝酮;

相似文献

外文文献
中文文献
专利

1. Diastereoselective synthesis of some carbocyclic 2′-oxa-3′-aza-nucleosides [J] . E. Hyrosova, L. Fisera, R. M.-A. Jame, Chemistry of heterocyclic compounds . 2007,第1期

机译：一些碳环2'-oxa-3'-氮杂-核苷的非对映选择性合成
2. Effect of phosphonated carbocyclic 2'-oxa-3'-aza-nucleoside on human T-cell leukemia virus type 1 infection in vitro. [J] . Balestrieri E, Matteucci C, Ascolani A, Antimicrobial agents and chemotherapy. . 2008,第1期

机译：磷酸化的碳环2'-oxa-3'-氮杂核苷在体外对人T细胞白血病病毒1型感染的影响。
3. Enantiomerically Pure Phosphonated Carbocyclic 2 '-Oxa-3 '-Azanucleosides: Synthesis and Biological Evaluation [J] . Romeo Roberto, Carnovale Caterina, Giofre Salvatore V., Molecules . 2014,第9期

机译：对映体纯的膦酰基碳环的2'-Oxa-3'-氮杂核苷：合成和生物学评价。
4. Diastereoselective Synthesis of α-Amino Amide Using the Umpolung Reaction of α-Hydrazono Ester [C] . Yusuke Nakamura, Isao Mizota, Makoto Shimizu 日本化学会春季年会講演予稿集 . 2018

机译：使用α-肼酯的umpolung反应，对α-氨基酰胺的非对抗合成α-氨基酰胺
5. Carbocyclic fleximers: The design and synthesis of a novel class of carbocyclic nucleosides. [D] . Zimmermann, Sarah Catherine. 2014

机译：碳环挠性分子：一类新型的碳环核苷的设计和合成。
6. Effect of Phosphonated Carbocyclic 2′-Oxa-3′-Aza-Nucleoside on Human T-Cell Leukemia Virus Type 1 Infection In Vitro [O] . Emanuela Balestrieri, Claudia Matteucci, Arianna Ascolani, 2008

机译：磷酸化的碳环2-Oxa-3-氮杂-核苷对人T细胞白血病病毒1型体外感染的影响
7. Synthesis of phosphonated carbocyclic 2 '-oxa-3 '-aza-nucleosides: Novel inhibitors of reverse transcriptase [O] . Chiacchio U, Balestrieri E, Macchi B, 2005

机译：磷酸化的碳环2'-oxa-3'-氮杂-核苷的合成：新型逆转录酶抑制剂
8. Synthesis of Carbocyclic 3-Deazaadenosine Analogs as Potential Agents Against Poxvirus [R] . Secrist, J. A. 2000

机译：作为抗痘病毒潜在药剂的碳环3-脱氮腺苷类似物的合成

Diastereoselective synthesis of some carbocyclic 2′-oxa-3′-aza-nucleosides

摘要

著录项

相似文献

相关主题

期刊订阅