Progression of aortic pulse wave velocity in patients with chronic kidney disease

TholenS.; KlofatK.; PanC.R.; SchmadererC.; LutzJ.; HeemannU.; BaumannM.

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Progression of aortic pulse wave velocity in patients with chronic kidney disease

机译：慢性肾脏病患者主动脉脉搏波速度的进展

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Aortic pulse wave velocity (aPWV) is elevated in patients with chronic kidney disease (CKD) and predicts cardiovascular risk. However, the natural progression of arterial stiffness in these patients remains uncertain. Therefore, the main aim of this study was to investigate the development of aPWV and to identify potential factors associated with its progression. aPWV measurement was carried out in 70 CKD patients at baseline and after 12 months. Correlations to several variables, in particular annual glomerular filtration rate reduction and diabetes mellitus, were studied. In the cohort, aPWV significantly increased in 1 year by 1.1 m/s (P<.01). Dividing the group into patients with stable and progressive aPWV, factors associated with accelerated progression were age, systolic blood pressure, and diabetes, whereas loss of renal function had no significant impact. The annual aPWV progression in CKD patients reached 1 m/s, which predicts an increased cardiovascular risk. Variables involved with progressive arterial stiffness need further evaluation.

机译：患有慢性肾脏疾病（CKD）的患者主动脉脉搏波速度（aPWV）升高，并预测心血管风险。然而，这些患者的动脉僵硬的自然进展仍然不确定。因此，这项研究的主要目的是调查aPWV的发展并确定与其进展相关的潜在因素。在基线和12个月后对70名CKD患者进行了aPWV测量。研究了与多个变量的相关性，特别是年度肾小球滤过率降低和糖尿病。在该队列中，aPWV在1年中显着增加了1.1 m / s（P <.01）。将患者分为稳定和进行性aPWV患者，与加速进展相关的因素是年龄，收缩压和糖尿病，而肾功能的丧失没有明显影响。 CKD患者的每年aPWV进程达到1 m / s，这预示着心血管风险增加。与进行性动脉僵硬有关的变量需要进一步评估。

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《The journal of clinical hypertension.》 |2013年第11期|共6页
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TholenS.; KlofatK.; PanC.R.; SchmadererC.; LutzJ.; HeemannU.; BaumannM.;
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中图分类心脏、血管（循环系）疾病;
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1. Progression of aortic pulse wave velocity in patients with chronic kidney disease [J] . TholenS., KlofatK., PanC.R., The journal of clinical hypertension. . 2013,第11期

机译：慢性肾脏病患者主动脉脉搏波速度的进展
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Progression of aortic pulse wave velocity in patients with chronic kidney disease

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