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首页> 外文会议>International Workshop on Breast Imaging >Prevalence, progression and implications of breast artery calcification in patients with chronic kidney disease across stages of disease
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Prevalence, progression and implications of breast artery calcification in patients with chronic kidney disease across stages of disease

机译：慢性肾脏病患者跨疾病阶段的乳腺动脉钙化的患病率，进展及其影响

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Breast artery calcification (BAC) is increasingly recognized as a specific marker of medial calcification and may help to identify risk factors of medial artery calcification. Amongst these are high age, diabetes mellitus, hypertension and chronic kidney disease (CKD). Present retrospective observational cohort study focused on the latter patient group with CKD and aimed to define the prevalence and progression rate of BAC in chronic kidney disease (CKD) patients across stages of disease, to define clinical and biochemical correlates of BAC and to explore the association of BAC with incident cardiovascular morbidity and mortality. The main findings of the present observational study are as follows: (a) BAC is common in CKD and its prevalence, severity and rate of progression increase parallel to the degree of kidney dysfunction; (b) inflammation and hyperphosphatemia are (nontraditional) risk factors for BAC in CKD patients; and (c) BAC associates with a dismal cardiovascular outcome in renal transplant recipients. In conclusion, BAC is common among CKD patients, progresses at a slower pace in Tx patients as compared to CKD5D patients, and associates with dismal cardiovascular outcomes. BAC score, kidney function and serum phosphate at baseline seem to be important determinants of progression. BAC is not routinely mentioned in mammogram reports, while the measurement of BAC may offer a personalized, non-invasive approach to risk-stratify CKD patients for cardiovascular disease at no additional cost or radiation since a majority of women over the age of 40 undergo regular breast cancer screening.
机译：乳腺动脉钙化（BAC）日益被认为是内侧钙化的特定标志物，可能有助于确定内侧动脉钙化的危险因素。其中包括高龄，糖尿病，高血压和慢性肾脏病（CKD）。目前的回顾性观察性队列研究集中于后者的CKD患者组，旨在确定慢性肾病（CKD）患者跨疾病各个阶段的BAC患病率和进展率，确定BAC的临床和生化相关性并探讨其相关性。 BAC与心血管疾病发病率和死亡率的关系。本观察性研究的主要发现如下：（a）BAC在CKD中很常见，其患病率，严重性和进展速度与肾功能不全程度平行增加; （b）炎症和高磷血症是CKD患者BAC的（非传统）危险因素; （c）BAC与肾移植接受者的心血管预后不良有关。总之，BAC在CKD患者中很常见，与CKD5D患者相比，Tx患者的进展较慢，并伴有心血管疾病的不良后果。基线时BAC评分，肾脏功能和血清磷酸盐似乎是进展的重要决定因素。 BAC在乳房X光照片报告中没有被例行提及，而BAC的测量可以提供个性化，非侵入性的方法来对CKD患者进行心血管疾病的风险分层，因为无需支付任何额外费用或进行放射治疗，因为大多数40岁以上的女性都接受了定期检查乳腺癌筛查。

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