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首页> 外文期刊>The journal of clinical hypertension. >Pheochromocytoma/Paraganglioma: Review of Perioperative Management of Blood Pressure and Update on Genetic Mutations Associated With Pheochromocytoma
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Pheochromocytoma/Paraganglioma: Review of Perioperative Management of Blood Pressure and Update on Genetic Mutations Associated With Pheochromocytoma

机译：嗜铬细胞瘤/旁淋巴瘤：围手术期血压管理和与嗜铬细胞瘤相关的遗传突变的更新

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摘要

Pheochromocytomas and paragangliomas are rare tumors with high morbidity rates caused by excessive catecholamine secretion, even though the majority of tumors are benign. The use of perioperative blockade regimens, together with improved surgical techniques, has greatly impacted the perioperative morbidity associated with these tumors. The old dogma of the "tumor of tens" no longer holds true. For example, at least one third of all pheochromocytomas and paragangliomas are hereditary, with mutations in 1 of 10 well-characterized susceptibility genes, and one quarter of all tumors are malignant. This review focuses on the perioperative management of pheochromocytoma and paragangliomas and the clinical implications of the associated genetic mutations.
机译：嗜铬细胞瘤和副神经节瘤是由儿茶酚胺分泌过多引起的高发病率的罕见肿瘤，尽管大多数肿瘤是良性的。围手术期封锁方案的使用以及改进的外科手术技术极大地影响了与这些肿瘤相关的围手术期发病率。 “十大肿瘤”的旧教条不再成立。例如，所有嗜铬细胞瘤和副神经节瘤中至少有三分之一是遗传性的，在10个特征明确的易感基因中有1个发生了突变，而所有肿瘤中有四分之一是恶性的。这篇综述着重于嗜铬细胞瘤和神经节瘤的围手术期管理以及相关基因突变的临床意义。

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