Rab7, a multifaceted GTP-binding protein regulating access to degradative compartments in eukaryotic cells

Bruckert F.; Satre M.; Laurent O.

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Rab7, a multifaceted GTP-binding protein regulating access to degradative compartments in eukaryotic cells

机译：Rab7，一种多面性的GTP结合蛋白，可调节进入真核细胞降解区室的途径

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Small GTPases of the Rab subfamily localise to the cytoplasmic face of distinct membrane compartments and act as regulators of intracellular membrane traffic and transport vesicle formation. Among them. Rab7 controls the delivery of internalised material into degradative compartments and the acquisition of lysosomal hydrolases. This activity shapes the endocytic pathway of every cell type. In addition, this general role may adjust to serve specific needs in multicellular organisms. [References: 66]

机译：Rab亚家族的小GTPases定位于不同膜区室的细胞质表面，并充当细胞内膜运输和运输囊泡形成的调节剂。其中。 Rab7控制内部化物质向降解区室的传递以及溶酶体水解酶的获取。这种活性决定了每种细胞类型的内吞途径。此外，此一般角色可能会进行调整，以满足多细胞生物中的特定需求。 [参考：66]

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《Protoplasma: An International Journal of Cell Biology》 |2000年第4期|共9页
作者
Bruckert F.; Satre M.; Laurent O.;
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正文语种 eng
中图分类细胞形态学;
关键词
Rab7 protein; Endocytosis; Phagocytosis; Lysosomal enzymes; Cation-independent mannose 6-phosphate receptor; Terminal truncated constructs; Early endocytic pathway; Dictyostelium-discoideum; Endosome fusion; T-snare; Vesicle transport; Bone-resorption; Membrane-fusion; Ruffled border; V-snare;

机译：Rab7蛋白;胞吞作用;吞噬作用;溶酶体酶;非阳离子依赖的甘露糖6-磷酸受体;末端截短的构建体;早期内吞途径;双歧杆菌-粘膜;内体融合;T-snare;囊泡运输;骨吸收;膜融合;皱纹边界;V型;

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1. Rab7, a multifaceted GTP-binding protein regulating access to degradative compartments in eukaryotic cells [J] . Bruckert F., Satre M., Laurent O. Protoplasma: An International Journal of Cell Biology . 2000,第3a4期

机译：Rab7，一种多面性的GTP结合蛋白，可调节进入真核细胞降解区室的途径
2. Comparative Genomics of Prokaryotic GTP-Binding Proteins (the Era, Obg, EngA, ThdF (TrmE), YchF and YihA Families) and their Relationship to Eukaryotic GTP-Binding Proteins (the DRG, ARF, RAB, RAN, RAS and RHO Families) [J] . Gerhard Mittenhuber Journal of molecular microbiology and biotechnology: JMMB . 2001,第1期

机译：GTP结合蛋白（Era，Obg，EngA，ThdF（TrmE），YchF和YihA家族）的比较基因组学及其与真核GTP结合蛋白（DRG，ARF，RAB，RAN，RAS和RHO家族）的关系
3. Effects of S-nitroso-cysteine on proteins that regulate exocytosis in PC12 cells: inhibitory effects on translocation of synaptophysin and ADP-ribosylation of GTP-binding proteins. [J] . Naganuma T, Maekawa M, Murayama T, Japanese Journal of Pharmacology . 2000,第4期

机译：S-亚硝基半胱氨酸对调节PC12细胞胞吐作用的蛋白质的影响：对突触素移位和GTP结合蛋白的ADP-核糖基化的抑制作用。
4. Exploring ATP- and GTP-binding proteins in human cell proteome with an affinitylabeled nucleotide probe [C] . Yongsheng XIAO, Yinsheng Wang American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：用亲和标记的核苷酸探针探索人细胞蛋白质组中的ATP和GTP结合蛋白
5. Regulation of the activation and activity of the extra-cellular signal regulated kinases 1 & 2 map kinase pathway by eukaryotic initiation factor 2 associated glycoprotein p67 [D] . Majumdar, Avijit 2008

机译：真核起始因子2相关糖蛋白p67对细胞外信号调节激酶1和2 map激酶途径活化和活性的调节
6. Specific Behavior of Intracellular Streptococcus pyogenes That Has Undergone Autophagic Degradation Is Associated with Bacterial Streptolysin O and Host Small G Proteins Rab5 and Rab7 [O] . Atsuo Sakurai, Fumito Maruyama, Junko Funao, 2010

机译：自噬降解已发生的细胞内化脓性链球菌的特定行为与细菌链球菌溶血素O和宿主小G蛋白Rab5和Rab7有关。
7. Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation [O] . Celina Amaya, Rodrigo D. Militello, Sebastián D. Calligaris, 2016

机译：Rab24与Rab7 / Rab相互作用的溶酶体蛋白质复合物，以调节内体降解
8. Assessment of the Activation State of Rho Family GTP-Binding Proteins in Breast Cancer Cells and Specimens [R] . Zheng, Y. 2004

机译：评估乳腺癌细胞和标本中Rho家族GTp结合蛋白的活化状态

Rab7, a multifaceted GTP-binding protein regulating access to degradative compartments in eukaryotic cells

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