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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >Morphometric investigations of sensory vestibular structures in tadpoles (Xenopus laevis) after a spaceflight: implications for microgravity-induced alterations of the vestibuloocular reflex
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Morphometric investigations of sensory vestibular structures in tadpoles (Xenopus laevis) after a spaceflight: implications for microgravity-induced alterations of the vestibuloocular reflex

机译：太空飞行后t（非洲爪蟾）的感觉前庭结构的形态计量学研究：对微重力诱导的前庭反射改变的影响

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摘要

In lower vertebrates, gravity deprivation by orbital flights modifies the vestibuloocular reflex. Using the amphibian Xenopus laevis, the experiments should clarify to which extent macular structures of the labyrinth are responsible for these modifications. In particular, the shape of otoconia and number and size of sensory macular cells expressing CalBindin were considered. CalBindin is common in mature sensory cells including vestibular hair cells and is probably involved in otoconia formation. Two developmental stages were used for this study: stage 26/27 embryos, which were unable to perform the roll-induced vestibuloocular reflex (rVOR) at onset of microgravity, and stage 45 tadpoles, which had already developed the reflex. The main observations were that the developmental progress of the animals was not affected by nncrogravity; that in the young tadpole group with normal body shape the NOR was not modified by microgravity, while in the older group with microgravity experience, the NOR was augmented; and that significant effects on the shape of otoconia and on the number and size of CalBindin-expressing cells of the labyrinthine maculae cells were absent. In addition, behavioural data were never significantly correlated with morphological features of macular structures Such as size and number of CalBindin-expressing cells. It is postulated that mechanisms of vestibular adaptation to microgravity during early development are probably based on mechanisms located in central structures of the vestibular system.
机译：在低等脊椎动物中，通过轨道飞行剥夺重力会改变前庭反射。使用两栖非洲爪蟾，实验应阐明迷宫的黄斑结构在多大程度上负责这些修饰。特别地，考虑了耳垢的形状以及表达CalBindin的感觉性黄斑细胞的数量和大小。 CalBindin在成熟的感觉细胞（包括前庭毛细胞）中很常见，并且可能参与耳垢的形成。这项研究使用了两个发育阶段：26/27期胚胎，在微重力作用下无法进行侧倾诱导的前庭反射（rVOR）; 45期already已经形成反射。主要观察结果是动物的发育进程不受重力的影响。在体形正常的年轻t组中，NOR不会受到微重力的影响，而在具有微重力经验的中老年，中，NOR会增强。缺少对耳垢的形状以及迷宫式黄斑细胞中表达CalBindin的细胞的数量和大小的显着影响。此外，行为数据从未与黄斑结构的形态特征（如表达CalBindin的细胞的大小和数量）显着相关。据推测，在早期发育过程中前庭适应微重力的机制可能是基于位于前庭系统中央结构的机制。

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