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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >Modulatory effects of Pycnogenol? in a rat model of insulin-dependent diabetes mellitus: Biochemical, histological, and immunohistochemical evidences
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Modulatory effects of Pycnogenol? in a rat model of insulin-dependent diabetes mellitus: Biochemical, histological, and immunohistochemical evidences

机译：碧萝ogen的调节作用？在胰岛素依赖型糖尿病大鼠模型中的作用：生化，组织学和免疫组化证据

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A number of experimental and clinical findings have consistently demonstrated the protective effects of Pycnogenol? (PYC) in the management of diabetes. However, the protective mechanism by which PYC provides protection in a model type I diabetes has not been studied. This study examines the beneficial effect of PYC on hyperglycemia, inflammatory markers, and oxidative damage in diabetic rats. We also evaluated the possible mechanism of action of PYC which might be that it stimulates beta islet expression, which has been implicated in the process of insulin secretion and diabetes management. Diabetes was induced in rats by an intraperitoneal injection of streptozotocin (STZ; 60 mg/kg body weight) followed by free access to 5 % glucose for the next 24 h. Four days after STZ injection, rats were supplemented with PYC (10 mg/kg body weight) for 4 weeks. At the end of the experiment, blood was drawn, and rats were then sacrificed, and their livers and pancreases were dissected for biochemical and histological assays. The level of fasting blood glucose and glycosylated hemoglobin significantly increased but amylase, insulin, and hepatic glycogen level decreased in the STZ group. PYC significantly augmented these effects in STZ + PYC group. The STZ group showed elevated level of nitric oxide, tumor necrosis factor-α, and interleukin-1beta in serum which were decreased by PYC treatment. Moreover, PYC significantly ameliorated increased thiobarbituric reactive substances, protein carbonyl, and decreased levels of glutathione, glutathione-s-transferase, and catalase activity in the liver and pancreas of the STZ rats. Histopathological and immunohistochemical examination also revealed a remarkable protective effect of PYC. The study suggests that PYC is effective in reducing diabetic-related complications in a type I model of diabetes and might be beneficial for the treatment of diabetic patients.
机译：大量的实验和临床发现一致证明碧容健？ （PYC）处理糖尿病。但是，尚未研究PYC在I型糖尿病模型中提供保护的保护机制。这项研究检查了PYC对糖尿病大鼠高血糖，炎性标志物和氧化损伤的有益作用。我们还评估了PYC可能的作用机制，可能是它刺激了β胰岛的表达，这与胰岛素分泌和糖尿病的治疗过程有关。通过腹膜内注射链脲佐菌素（STZ; 60 mg / kg体重）在大鼠中诱发糖尿病，然后在接下来的24小时内自由摄入5％的葡萄糖。注射STZ后四天，向大鼠补充PYC（10 mg / kg体重），持续4周。实验结束时，抽血，然后处死大鼠，解剖其肝脏和胰脏以进行生化和组织学分析。空腹血糖和糖基化血红蛋白水平显着升高，但STZ组的淀粉酶，胰岛素和肝糖原水平降低。 PYC显着增强了STZ + PYC组的这些作用。 STZ组显示血清中一氧化氮，肿瘤坏死因子-α和白介素-1β的水平升高，而PYC处理则降低了这些水平。此外，PYC可以显着改善STZ大鼠肝脏和胰腺中硫代巴比妥活性物质，蛋白质羰基的增加以及谷胱甘肽，谷胱甘肽S-转移酶和过氧化氢酶活性的降低。组织病理学和免疫组化检查也显示了PYC的显着保护作用。研究表明，PYC可有效减少I型糖尿病模型中与糖尿病相关的并发症，并且可能对糖尿病患者的治疗有益。

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