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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >A comparative study of PNIPAM nanoparticles of curcumin, demethoxycurcumin, and bisdemethoxycurcumin and their effects on oxidative stress markers in experimental stroke
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A comparative study of PNIPAM nanoparticles of curcumin, demethoxycurcumin, and bisdemethoxycurcumin and their effects on oxidative stress markers in experimental stroke

机译：姜黄素，去甲氧基姜黄素和双去甲氧基姜黄素的PNIPAM纳米粒子的比较研究及其对实验性卒中氧化应激指标的影响

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Oxidative stress and inflammatory damage play an important role in cerebral ischemic pathogenesis and may represent a target for treatment. The development of new strategies for enhancing drug delivery to the brain is of great importance in diagnostics and therapeutics of central nervous diseases. The present study examined the hypothesis that intranasal delivery of nanoformulation of curcuminoids would reduce oxidative stress-associated brain injury after middle cerebral artery occlusion (MCAO). The rats were subjected to 2 h of MCAO followed by 22 h reperfusion, after which the grip strength, locomotor activity was performed. The effects of treatment in the rats were assessed by grip strength, locomotor activity and biochemical studies (glutathione peroxidase, glutathione reductase, lipid peroxidation, superoxide dismutase, and catalase) in the brain. Pretreatment with polymeric N-isopropyl acryl amide (PNIPAM) nanoparticles formulation of all three curcuminoids (curcumin (Cur), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC)) at doses (100 μg/kg body weight) given intranasally was effective in bringing significant changes on all the parameters. While nanoformulation of curcumin at a dose of 100 μg/kg body weight was most active in the treatment of cerebral ischemia as compared to others nanoformulation of curcuminoids. The potency of antioxidant activity significantly decreased in the order of PNIPAM nanoformulation of Cur > DMC BDMC, thus suggesting the critical role of methoxy groups on the phenyl ring.
机译：氧化应激和炎性损害在脑缺血性发病机制中起重要作用，并且可能代表治疗目标。在中枢神经疾病的诊断和治疗中，开发增强对大脑的药物输送的新策略的开发非常重要。本研究检验了以下假设：鼻内递送姜黄素类纳米制剂将减少大脑中动脉闭塞（MCAO）后与氧化应激相关的脑损伤。大鼠接受MCAO 2 h，再灌注22 h，之后进行抓地力，运动能力。通过大鼠的握力，运动活动和生化研究（谷胱甘肽过氧化物酶，谷胱甘肽还原酶，脂质过氧化，超氧化物歧化酶和过氧化氢酶）评估了对大鼠的治疗效果。鼻内给予剂量（100μg/ kg体重）的所有三种姜黄素类化合物（姜黄素（Cur），去甲氧基姜黄素（DMC）和双去甲氧基姜黄素（BDMC））的聚合N-异丙基丙烯酰胺（PNIPAM）纳米颗粒制剂进行预处理均有效所有参数都有重大变化。与其他姜黄素类纳米制剂相比，剂量为100μg/ kg体重的姜黄素纳米制剂在脑缺血的治疗中最为活跃。抗氧化剂活性的强度以Cur> DMC BDMC的PNIPAM纳米配方的顺序显着降低，从而表明苯环上甲氧基的关键作用。

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