• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >P53 protein in proliferation, repair and apoptosis of cells
【24h】

P53 protein in proliferation, repair and apoptosis of cells

机译：P53蛋白在细胞增殖，修复和凋亡中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The p53 protein is an important factor of many intraand extracellular processes. This protein regulates the repair of cellular DNA and induces apoptosis. It is also responsible for the regulation of the senescence and the cell entering the subsequent stages of the cellular cycle. The protein p53 is also involved in inhibiting angiogenesis and the induction of oxidative shock. In our study, we examined the activity of p53 protein in the uterine epithelial cells in rats treated with cladribine. Its action is mainly based on apoptosis induction. We compared the activity of p53 protein in cells with a high apoptosis index and in cells with active repair mechanisms and high proliferation index. We observed stronger p53 protein expression in the epithelial cells of the materials taken 24 h after the last dose of 2-CdA associated with the active process of apoptosis and inhibition of proliferation. After 4 weeks from the last dose of cladribine, the stronger expression of p53 protein was associated with both the existing changes in the cell's genome, the effects of the ongoing repair mechanisms, as well as the high proliferation activity.
机译：p53蛋白是许多细胞内和细胞外过程的重要因素。这种蛋白质调节细胞DNA的修复并诱导凋亡。它还负责调节衰老和进入细胞周期后续阶段的细胞。 p53蛋白还参与抑制血管生成和氧化休克的诱导。在我们的研究中，我们检查了克拉屈滨治疗的大鼠子宫上皮细胞中p53蛋白的活性。其作用主要基于细胞凋亡的诱导。我们比较了具有高凋亡指数的细胞和具有主动修复机制和高增殖指数的细胞中p53蛋白的活性。我们观察到在最后一次注射2-CdA后24小时，材料的上皮细胞中p53蛋白表达增强，这与细胞凋亡和增殖抑制过程有关。从最后一次使用克拉屈滨开始服用4周后，p53蛋白的更强表达与细胞基因组中的现有变化，正在进行的修复机制以及高增殖活性有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号