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首页> 外文期刊>The journal of hand surgery. British and European volume: Journal of the British Society for Surgery of the Hand >Dupuytren's disease risk factors.
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Dupuytren's disease risk factors.

机译：Dupuytren疾病的危险因素。

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摘要

Dupuytren's is a common problem, but little is known about its aetiology. We have undertaken a large case-control study to assess and quantify the relative contributions of diabetes and epilepsy as risk factors for Dupuytren's in the community. Cases were patients with a diagnosis of Dupuytren's disease and, for each, two controls were individually matched by age, sex, and general practice. Our dataset included 821 cases and 1,642 controls. Five hundred and eighty-eight (72%) of the cases were men. The mean age at diagnosis was 62 (range 24-97) years. Diabetes was a significant risk factor for Dupuytren's disease (OR=1.75) and there was an increased risk for medicinally treated diabetes (metformin--OR=3.56; sulphonylureas--OR=1.75) and particularly insulin controlled (OR=4.38) rather than diet-controlled diabetes. Epilepsy (OR=1.12) and anti-epileptic medications were not associated with Dupuytren's disease. Ascertainment bias in previous studies may explain the reported association with epilepsy.
机译：Dupuytren病是一个常见问题，但对其病因学知之甚少。我们进行了一项大型病例对照研究，以评估和量化糖尿病和癫痫病作为社区中Dupuytren的危险因素的相对贡献。病例为诊断为Dupuytren病的患者，每个患者均按年龄，性别和一般习惯分别匹配两个对照。我们的数据集包括821个案例和1,642个控件。 588例（72％）是男性。诊断时的平均年龄为62岁（范围24-97）。糖尿病是Dupuytren病的重要危险因素（OR = 1.75），药物治疗的糖尿病（二甲双胍-OR = 3.56;磺酰脲类药物-OR = 1.75）尤其是胰岛素控制（OR = 4.38）升高了饮食控制型糖尿病。癫痫（OR = 1.12）和抗癫痫药物与Dupuytren病无关。先前研究中的确定性偏倚可能解释了与癫痫有关的报道。

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