Atroviridins A#approx#C and Neoatroviridins A#approx#D, Novel Peptaibol Antibiotics

Seung-Uk Oh; Bong-Sik Yun; Sang-Jun Lee; Jng-Han Kim; Ick-Dong Yoo

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Atroviridins A#approx#C and Neoatroviridins A#approx#D, Novel Peptaibol Antibiotics

机译：Atroviridins A＃approx＃C和Neoatroviridins A＃approx＃D，新型Peptaibol抗生素

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Seven new peptaibols, atroviridins AapproxC and of 20 residue amino acids and neoatroviridins AapproxD with 18 residues, were isolated from the culture broth of fungal strain F80317. The strain F80317 was identified s Trichoderma atroviride fro its morphological and cultural characteristics. These compounds showed antimicrobial activity against Grampositive bacteria and phytopathogenic fungi, and exhibited significant cytotoxicity to human cancer cell lines in vitro. Atroviridins showed significant membrane-perturbing activity responsible to their antibiotic action.

机译：从真菌菌株F80317的培养液中分离出7种新的肽醇，阿托维里定AapproxC和20个残基氨基酸，以及新阿托维里丁AapproxD具有18个残基。 F80317菌株由其形态和培养特性鉴定为阿氏木霉。这些化合物对革兰氏阳性菌和植物致病真菌具有抗微生物活性，并且在体外对人癌细胞系具有显着的细胞毒性。 Atroviridins显示出显着的膜扰动活性对其抗生素作用负责。

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《The Journal of Antibiotics: An International Journal》 |2002年第6期|共8页
作者
Seung-Uk Oh; Bong-Sik Yun; Sang-Jun Lee; Jng-Han Kim; Ick-Dong Yoo;
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正文语种 eng
中图分类药学;药品;
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1. Atroviridins A#approx#C and Neoatroviridins A#approx#D, Novel Peptaibol Antibiotics [J] . Seung-Uk Oh, Bong-Sik Yun, Sang-Jun Lee, The Journal of Antibiotics: An International Journal . 2002,第6期

机译：Atroviridins A＃approx＃C和Neoatroviridins A＃approx＃D，新型Peptaibol抗生素
2. The antibiotic peptaibol alamethicin from Trichoderma permeabilises Arabidopsis root apical meristem and epidermis but is antagonised by cellulase-induced resistance to alamethicin [J] . Bradley R. Dotson, Dia Soltan, John Schmidt, BMC Plant Biology . 2018,第1期

机译：木霉通透性的抗菌肽肽抑菌素来抑制拟南芥的根尖分生组织和表皮，但被纤维素酶诱导的对抑菌素的抗性所拮抗
3. The antibiotic peptaibol alamethicin from Trichoderma permeabilises Arabidopsis root apical meristem and epidermis but is antagonised by cellulase-induced resistance to alamethicin [J] . Bradley R. Dotson, Dia Soltan, John Schmidt, BMC Plant Biology . 2018,第1期

机译：木霉通透性的抗菌肽肽抑菌素来抑制拟南芥的根尖分生组织和表皮，但被纤维素酶诱导的对抑菌素的抗性所拮抗
4. Sequences of peptaibol antibiotics trichobrachins [C] . Corina Krause, Nina Lodahl, Jochen Kirschbaum International Peptide Symposium;European Peptide Symposium . 2005

机译：乳酸抗生素序列Trichobrachins
5. Trends in Antibiotic Resistance and Correlations of Antibiotic Use and Antibiotic Resistance in a Small Hospital in El Paso, Texas 2013-2015 [D] . Olivas, Christopher Robert. 2018

机译：2013-2015年德克萨斯州埃尔帕索一家小型医院的抗生素耐药性趋势以及抗生素使用与抗生素耐药性的关系
6. The antibiotic peptaibol alamethicin from Trichoderma permeabilises Arabidopsis root apical meristem and epidermis but is antagonised by cellulase-induced resistance to alamethicin [O] . Bradley R. Dotson, Dia Soltan, John Schmidt, 2018

机译：木霉通透性的抗菌肽肽抑菌素来抑制拟南芥的根尖分生组织和表皮但被纤维素酶诱导的对抑菌素的抗性所拮抗
7. Cellular and molecular insight into the inhibition of primary root growth of Arabidopsis induced by peptaibols, a class of linear peptide antibiotics mainly produced byTrichodermaspp. [O] . Wei-Ling Shi, Xiu-Lan Chen, Li-Xia Wang, 2016

机译：细胞和分子洞察抑制Pestibols诱导的拟南芥原发性生长，一类线性肽抗生素主要产生Bytrichodermaspp。

Atroviridins A#approx#C and Neoatroviridins A#approx#D, Novel Peptaibol Antibiotics

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