N(2)-Substituted D,L-Cycloserine Derivatives: Synthesis and Evaluation as Alanine Racemase Inhibitors

Myoung Goo Kim; Ulrich Strych; Kurt Krause; Michael Benedik; Harold Kohn

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N(2)-Substituted D,L-Cycloserine Derivatives: Synthesis and Evaluation as Alanine Racemase Inhibitors

机译：N（2）取代的D，L-环丝氨酸衍生物：合成和评估为丙氨酸消旋酶抑制剂。

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A select series of N(2)-substituted D,L-cycloserine derivatives were prepared and evaluated for inhibitory activity against purified alanine racemases (alr gene product) from Escherichia coli, Staphylococcus aureus, and Mycobacterium tuberculosis, as well as in a growth inhibition assay. N(2)-Modification led to loss of enzymatic inhbitory activity in most cases consistent with a recent proposal for cycloserine function.

机译：制备一系列选择的N（2）-取代的D，L-环丝氨酸衍生物，并评估其对大肠杆菌，金黄色葡萄球菌和结核分枝杆菌的纯化的丙氨酸消旋体（alr基因产物）的抑制活性以及对生长的抑制作用分析。在大多数情况下，N（2）-修饰导致酶促酶活性丧失，这与最近关于环丝氨酸功能的提议一致。

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来源
《The Journal of Antibiotics: An International Journal》 |2003年第2期|共9页
作者
Myoung Goo Kim; Ulrich Strych; Kurt Krause; Michael Benedik; Harold Kohn;
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正文语种 eng
中图分类药学;药品;
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1. N(2)-Substituted D,L-Cycloserine Derivatives: Synthesis and Evaluation as Alanine Racemase Inhibitors [J] . Myoung Goo Kim, Ulrich Strych, Kurt Krause, The Journal of Antibiotics: An International Journal . 2003,第2期

机译：N（2）取代的D，L-环丝氨酸衍生物：合成和评估为丙氨酸消旋酶抑制剂。
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N(2)-Substituted D,L-Cycloserine Derivatives: Synthesis and Evaluation as Alanine Racemase Inhibitors

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